Lack of association of interleukin-10 promoter region polymorphisms with Alzheimer's disease

Candan Depboylu, Yansheng Du, Ulrich Müller, Alexander Kurz, Reinhilde Zimmer, Matthias Riemenschneider, Thomas Gasser, Wolfgang H. Oertelf, Thomas Klockgether, Richard C. Dodel

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

There is increasing evidence that immune mechanisms are involved in the pathogenesis of Alzheimer's disease (AD). Recently, polymorphisms of the interleukin (IL)-1 and IL-6 genes were found to be associated with late-onset AD. The immunoregulatory IL-10 downregulates synthesis of pro-inflammatory cytokines such as IL-1. Current evidence suggests that some polymorphisms in the IL-10 promoter may have functional effects on IL-10 transcription. A total of 406 German AD patients (mean age 70.2±10.0 years, range 50-95 years, 42% female) and 251 unrelated non-demented control subjects (mean age 66.8±10.6 years, range 50-93 years, 38% female) were investigated for the presence of three polymorphisms in the IL-10 promoter region (-1087A/G, -824C/T, -597C/A). No significant differences in the allelic distribution of the analyzed IL-10 polymorphisms have been found between AD patients and controls. We conclude that polymorphisms in the IL-10 promoter region do not increase the risk of developing AD.

Original languageEnglish
Pages (from-to)132-134
Number of pages3
JournalNeuroscience Letters
Volume342
Issue number1-2
DOIs
StatePublished - May 15 2003

Fingerprint

Genetic Promoter Regions
Interleukin-10
Alzheimer Disease
Interleukin-1
Interleukin-6
Down-Regulation
Cytokines
Genes

Keywords

  • Alzheimer's disease
  • Cytokine
  • Dementia
  • Inflammation
  • Interleukin
  • Polymorphism
  • Pro-inflammatory

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Depboylu, C., Du, Y., Müller, U., Kurz, A., Zimmer, R., Riemenschneider, M., ... Dodel, R. C. (2003). Lack of association of interleukin-10 promoter region polymorphisms with Alzheimer's disease. Neuroscience Letters, 342(1-2), 132-134. https://doi.org/10.1016/S0304-3940(03)00231-3

Lack of association of interleukin-10 promoter region polymorphisms with Alzheimer's disease. / Depboylu, Candan; Du, Yansheng; Müller, Ulrich; Kurz, Alexander; Zimmer, Reinhilde; Riemenschneider, Matthias; Gasser, Thomas; Oertelf, Wolfgang H.; Klockgether, Thomas; Dodel, Richard C.

In: Neuroscience Letters, Vol. 342, No. 1-2, 15.05.2003, p. 132-134.

Research output: Contribution to journalArticle

Depboylu, C, Du, Y, Müller, U, Kurz, A, Zimmer, R, Riemenschneider, M, Gasser, T, Oertelf, WH, Klockgether, T & Dodel, RC 2003, 'Lack of association of interleukin-10 promoter region polymorphisms with Alzheimer's disease', Neuroscience Letters, vol. 342, no. 1-2, pp. 132-134. https://doi.org/10.1016/S0304-3940(03)00231-3
Depboylu, Candan ; Du, Yansheng ; Müller, Ulrich ; Kurz, Alexander ; Zimmer, Reinhilde ; Riemenschneider, Matthias ; Gasser, Thomas ; Oertelf, Wolfgang H. ; Klockgether, Thomas ; Dodel, Richard C. / Lack of association of interleukin-10 promoter region polymorphisms with Alzheimer's disease. In: Neuroscience Letters. 2003 ; Vol. 342, No. 1-2. pp. 132-134.
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