Lack of association of interleukin-10 promoter region polymorphisms with Alzheimer's disease

Candan Depboylu, Yansheng Du, Ulrich Müller, Alexander Kurz, Reinhilde Zimmer, Matthias Riemenschneider, Thomas Gasser, Wolfgang H. Oertelf, Thomas Klockgether, Richard C. Dodel

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

There is increasing evidence that immune mechanisms are involved in the pathogenesis of Alzheimer's disease (AD). Recently, polymorphisms of the interleukin (IL)-1 and IL-6 genes were found to be associated with late-onset AD. The immunoregulatory IL-10 downregulates synthesis of pro-inflammatory cytokines such as IL-1. Current evidence suggests that some polymorphisms in the IL-10 promoter may have functional effects on IL-10 transcription. A total of 406 German AD patients (mean age 70.2±10.0 years, range 50-95 years, 42% female) and 251 unrelated non-demented control subjects (mean age 66.8±10.6 years, range 50-93 years, 38% female) were investigated for the presence of three polymorphisms in the IL-10 promoter region (-1087A/G, -824C/T, -597C/A). No significant differences in the allelic distribution of the analyzed IL-10 polymorphisms have been found between AD patients and controls. We conclude that polymorphisms in the IL-10 promoter region do not increase the risk of developing AD.

Original languageEnglish (US)
Pages (from-to)132-134
Number of pages3
JournalNeuroscience Letters
Volume342
Issue number1-2
DOIs
StatePublished - May 15 2003

Keywords

  • Alzheimer's disease
  • Cytokine
  • Dementia
  • Inflammation
  • Interleukin
  • Polymorphism
  • Pro-inflammatory

ASJC Scopus subject areas

  • Neuroscience(all)

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  • Cite this

    Depboylu, C., Du, Y., Müller, U., Kurz, A., Zimmer, R., Riemenschneider, M., Gasser, T., Oertelf, W. H., Klockgether, T., & Dodel, R. C. (2003). Lack of association of interleukin-10 promoter region polymorphisms with Alzheimer's disease. Neuroscience Letters, 342(1-2), 132-134. https://doi.org/10.1016/S0304-3940(03)00231-3