Lack of cross-reactivity of antibodies to ribosomal preparations from Streptococcus mutans with human heart and kidney antigens

Richard Gregory, I. L. Shechmeister, J. O. Brubaker, C. T. Smedberg, S. M. Michalek, J. R. McGhee

Research output: Contribution to journalArticle

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Abstract

Previous studies have suggested that sera from animals immunized with whole Streptococcus mutans cells may cross-react with human and monkey heart sarcolemmal tissues. In the present study, sera and saliva from rats and rabbits immunized peripherally with ribosomal preparations from S. mutans 6715 (serotype g) or GS-5 (serotype c) were examined for their ability to react with normal human heart sarcolemmal and kidney glomerular tissues by using enzyme-linked immunosorbent and immunofluorescence assays. The results showed that antibodies to serotype g and c ribosomal preparations do not react with either the human heart or renal antigens. Sera from mice immunized with human heart tissue and from a patient with a high anti-streptolysin O titer reacted strongly with human heart sarcolemmal and kidney glomerular tissues. These data indicated that ribosomal preparations from S. mutans lack the putative human heart cross-reactive determinant and suggest that the use of an S. mutans ribosomal vaccine against dental caries may not be pathogenic to human heart or renal tissues.

Original languageEnglish (US)
Pages (from-to)42-47
Number of pages6
JournalInfection and Immunity
Volume46
Issue number1
StatePublished - 1984
Externally publishedYes

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Streptococcus mutans
Kidney
Antigens
Antibodies
Serum
Dental Caries
Saliva
Haplorhini
Fluorescent Antibody Technique
Vaccines
Enzyme-Linked Immunosorbent Assay
Rabbits
Serogroup

ASJC Scopus subject areas

  • Immunology

Cite this

Gregory, R., Shechmeister, I. L., Brubaker, J. O., Smedberg, C. T., Michalek, S. M., & McGhee, J. R. (1984). Lack of cross-reactivity of antibodies to ribosomal preparations from Streptococcus mutans with human heart and kidney antigens. Infection and Immunity, 46(1), 42-47.

Lack of cross-reactivity of antibodies to ribosomal preparations from Streptococcus mutans with human heart and kidney antigens. / Gregory, Richard; Shechmeister, I. L.; Brubaker, J. O.; Smedberg, C. T.; Michalek, S. M.; McGhee, J. R.

In: Infection and Immunity, Vol. 46, No. 1, 1984, p. 42-47.

Research output: Contribution to journalArticle

Gregory, R, Shechmeister, IL, Brubaker, JO, Smedberg, CT, Michalek, SM & McGhee, JR 1984, 'Lack of cross-reactivity of antibodies to ribosomal preparations from Streptococcus mutans with human heart and kidney antigens', Infection and Immunity, vol. 46, no. 1, pp. 42-47.
Gregory, Richard ; Shechmeister, I. L. ; Brubaker, J. O. ; Smedberg, C. T. ; Michalek, S. M. ; McGhee, J. R. / Lack of cross-reactivity of antibodies to ribosomal preparations from Streptococcus mutans with human heart and kidney antigens. In: Infection and Immunity. 1984 ; Vol. 46, No. 1. pp. 42-47.
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AU - Michalek, S. M.

AU - McGhee, J. R.

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