Lack of effect of olanzapine on the pharmacokinetics of a single aminophylline dose in healthy men

William L. Macias, Richard F. Bergstrom, Benito J. Cerimele, Kelem Kassahun, David E. Tatum, John Callaghan

Research output: Contribution to journalArticle

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Abstract

Study Objective. To test whether olanzapine, an atypical antipsychotic, is an inhibitor of cytochrome P450 (CYP) 1A2 activity, we conducted a drug interaction study with theophylline, a known CYP1A2 substrate. Design. Two- way, randomized, crossover study. Setting. Clinical research laboratory. Subjects. Nineteen healthy males (16 smokers, 3 nonsmokers). Interventions. Because the a priori expectation was no effect of olanzapine on theophylline pharmacokinetics, a parallel study using cimetidine was included as a positive control. In group 1, 12 healthy subjects received a 30-minute intravenous infusion of aminophylline 350 mg after 9 consecutive days of either olanzapine or placebo. In group 2, seven healthy subjects received a similar aminophylline infusion after 9 consecutive days of either cimetidine or placebo. Measurements and Main Results. Concentrations of theophylline and its metabolites in serum and urine were measured for 24 and 72 hours, respectively Plasma concentrations of olanzapine and its metabolites were measured for 24 hours after the next to last dose and 168 hours after the last olanzapine dose. Olanzapine did not affect theophylline pharmacokinetics. However, cimetidine significantly decreased theophylline clearance and the corresponding formation of its metabolites. Urinary excretion of theophylline and its metabolites was unaffected by olanzapine but was reduced significantly by cimetidine. Steady-state concentrations of olanzapine (15.3 ng/ml), 10-N-glucuronide (4.9 ng/ml), and 4'-N-desmethyl olanzapine (2.5 ng/ml) were observed after olanzapine 10 mg once/day and were unaffected by coadministration of theophylline. Conclusion. As predicted by in vitro studies, steady-state concentrations of olanzapine and its metabolites did not affect theophylline pharmacokinetics and should not affect the pharmacokinetics of other agents metabolized by the CYP1A2 isozyme.

Original languageEnglish
Pages (from-to)1237-1248
Number of pages12
JournalPharmacotherapy
Volume18
Issue number6 I
StatePublished - Nov 1998
Externally publishedYes

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olanzapine
Aminophylline
Theophylline
Pharmacokinetics
Cimetidine
Cytochrome P-450 CYP1A2
Healthy Volunteers
Placebos
Glucuronides

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Macias, W. L., Bergstrom, R. F., Cerimele, B. J., Kassahun, K., Tatum, D. E., & Callaghan, J. (1998). Lack of effect of olanzapine on the pharmacokinetics of a single aminophylline dose in healthy men. Pharmacotherapy, 18(6 I), 1237-1248.

Lack of effect of olanzapine on the pharmacokinetics of a single aminophylline dose in healthy men. / Macias, William L.; Bergstrom, Richard F.; Cerimele, Benito J.; Kassahun, Kelem; Tatum, David E.; Callaghan, John.

In: Pharmacotherapy, Vol. 18, No. 6 I, 11.1998, p. 1237-1248.

Research output: Contribution to journalArticle

Macias, WL, Bergstrom, RF, Cerimele, BJ, Kassahun, K, Tatum, DE & Callaghan, J 1998, 'Lack of effect of olanzapine on the pharmacokinetics of a single aminophylline dose in healthy men', Pharmacotherapy, vol. 18, no. 6 I, pp. 1237-1248.
Macias WL, Bergstrom RF, Cerimele BJ, Kassahun K, Tatum DE, Callaghan J. Lack of effect of olanzapine on the pharmacokinetics of a single aminophylline dose in healthy men. Pharmacotherapy. 1998 Nov;18(6 I):1237-1248.
Macias, William L. ; Bergstrom, Richard F. ; Cerimele, Benito J. ; Kassahun, Kelem ; Tatum, David E. ; Callaghan, John. / Lack of effect of olanzapine on the pharmacokinetics of a single aminophylline dose in healthy men. In: Pharmacotherapy. 1998 ; Vol. 18, No. 6 I. pp. 1237-1248.
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