Lack of EGF receptor contributes to drug sensitivity of human germline cells

S. J. Park, S. Armstrong, C. H. Kim, M. Yu, K. Robertson, M. R. Kelley, S. H. Lee

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Germline mutations have been associated with generation of various types of tumour. In this study, we investigated genetic alteration of germline tumours that affect the drug sensitivity of cells. Although all germline tumour cells we tested were hypersensitive to DNA-damaging drugs, no significant alteration was observed in their DNA repair activity or the expression of DNA repair proteins. In contrast, germline tumours expressed very low level of epidermal growth factor receptor (EGFR) compared to drug-resistant ovarian cancer cells. An immunohistochemical analysis indicated that most of the primary germline tumours we tested expressed very low level of EGFR. In accordance with this, overexpression of EGFR in germline tumour cells showed an increase in drug resistance, suggesting that a lack of EGFR, at least in part, contributes to the drug sensitivity of germline tumours.

Original languageEnglish (US)
Pages (from-to)334-341
Number of pages8
JournalBritish Journal of Cancer
Volume92
Issue number2
DOIs
StatePublished - Jan 31 2005

Keywords

  • Cancer chemotherapy
  • Cisplatin
  • DNA damage
  • Drug resistance
  • Epidermal growth factor receptor

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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