Lack of mortality in 22 children with sickle cell anemia and severe malarial anemia

Robert O. Opoka, Paul Bangirana, Richard Idro, Estela Shabani, Ruth Namazzi, Chandy John

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Retrospective studies suggest that there is high mortality in children with sickle cell anemia (SCA) and severe malaria. We assessed mortality in Ugandan children with severe malarial anemia (SMA, n = 232) or cerebral malaria (CM, n = 267) by sickle cell hemoglobin genotype. Admission and 2-year follow-up mortality did not differ among children with SMA who had homozygous form of sickle cell hemoglobin (HbSS) versus normal form of adult hemoglobin (admission, 0/22, 0%, vs. 1/208, 0.5%; follow-up, 1/22, 4.5%; 7/207, 3.4%, respectively; all P > 0.6). The single child with CM and HbSS survived. The study findings highlight the need for large prospective studies of malaria-related mortality in children with SCA.

Original languageEnglish (US)
Article numbere26745
JournalPediatric Blood and Cancer
Volume65
Issue number1
DOIs
StatePublished - Jan 1 2018

Fingerprint

Sickle Cell Anemia
Sickle Hemoglobin
Anemia
Child Mortality
Malaria
Mortality
Cerebral Malaria
Hemoglobins
Retrospective Studies
Genotype
Prospective Studies

Keywords

  • mortality
  • severe malaria
  • sickle cell disease

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

Cite this

Lack of mortality in 22 children with sickle cell anemia and severe malarial anemia. / Opoka, Robert O.; Bangirana, Paul; Idro, Richard; Shabani, Estela; Namazzi, Ruth; John, Chandy.

In: Pediatric Blood and Cancer, Vol. 65, No. 1, e26745, 01.01.2018.

Research output: Contribution to journalArticle

Opoka, Robert O. ; Bangirana, Paul ; Idro, Richard ; Shabani, Estela ; Namazzi, Ruth ; John, Chandy. / Lack of mortality in 22 children with sickle cell anemia and severe malarial anemia. In: Pediatric Blood and Cancer. 2018 ; Vol. 65, No. 1.
@article{c31138604bc3468881916e8bc4eb1425,
title = "Lack of mortality in 22 children with sickle cell anemia and severe malarial anemia",
abstract = "Retrospective studies suggest that there is high mortality in children with sickle cell anemia (SCA) and severe malaria. We assessed mortality in Ugandan children with severe malarial anemia (SMA, n = 232) or cerebral malaria (CM, n = 267) by sickle cell hemoglobin genotype. Admission and 2-year follow-up mortality did not differ among children with SMA who had homozygous form of sickle cell hemoglobin (HbSS) versus normal form of adult hemoglobin (admission, 0/22, 0{\%}, vs. 1/208, 0.5{\%}; follow-up, 1/22, 4.5{\%}; 7/207, 3.4{\%}, respectively; all P > 0.6). The single child with CM and HbSS survived. The study findings highlight the need for large prospective studies of malaria-related mortality in children with SCA.",
keywords = "mortality, severe malaria, sickle cell disease",
author = "Opoka, {Robert O.} and Paul Bangirana and Richard Idro and Estela Shabani and Ruth Namazzi and Chandy John",
year = "2018",
month = "1",
day = "1",
doi = "10.1002/pbc.26745",
language = "English (US)",
volume = "65",
journal = "Pediatric Blood and Cancer",
issn = "1545-5009",
publisher = "Wiley-Liss Inc.",
number = "1",

}

TY - JOUR

T1 - Lack of mortality in 22 children with sickle cell anemia and severe malarial anemia

AU - Opoka, Robert O.

AU - Bangirana, Paul

AU - Idro, Richard

AU - Shabani, Estela

AU - Namazzi, Ruth

AU - John, Chandy

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Retrospective studies suggest that there is high mortality in children with sickle cell anemia (SCA) and severe malaria. We assessed mortality in Ugandan children with severe malarial anemia (SMA, n = 232) or cerebral malaria (CM, n = 267) by sickle cell hemoglobin genotype. Admission and 2-year follow-up mortality did not differ among children with SMA who had homozygous form of sickle cell hemoglobin (HbSS) versus normal form of adult hemoglobin (admission, 0/22, 0%, vs. 1/208, 0.5%; follow-up, 1/22, 4.5%; 7/207, 3.4%, respectively; all P > 0.6). The single child with CM and HbSS survived. The study findings highlight the need for large prospective studies of malaria-related mortality in children with SCA.

AB - Retrospective studies suggest that there is high mortality in children with sickle cell anemia (SCA) and severe malaria. We assessed mortality in Ugandan children with severe malarial anemia (SMA, n = 232) or cerebral malaria (CM, n = 267) by sickle cell hemoglobin genotype. Admission and 2-year follow-up mortality did not differ among children with SMA who had homozygous form of sickle cell hemoglobin (HbSS) versus normal form of adult hemoglobin (admission, 0/22, 0%, vs. 1/208, 0.5%; follow-up, 1/22, 4.5%; 7/207, 3.4%, respectively; all P > 0.6). The single child with CM and HbSS survived. The study findings highlight the need for large prospective studies of malaria-related mortality in children with SCA.

KW - mortality

KW - severe malaria

KW - sickle cell disease

UR - http://www.scopus.com/inward/record.url?scp=85034959146&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85034959146&partnerID=8YFLogxK

U2 - 10.1002/pbc.26745

DO - 10.1002/pbc.26745

M3 - Article

C2 - 28834130

AN - SCOPUS:85034959146

VL - 65

JO - Pediatric Blood and Cancer

JF - Pediatric Blood and Cancer

SN - 1545-5009

IS - 1

M1 - e26745

ER -