Lack of spontaneous ocular neovascularization and attenuated laser-induced choroidal neovascularization in IGF-I overexpression transgenic mice

Wenzheng Hu, Wei Wang, Hua Gao, Jin Zhong, Weiguo Yao, Wei Hua Lee, Ping Ye, Xiaoxi Qiao

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Robust IGF-I overexpression induces ocular angiogenesis in mice. To investigate the effect of subtle IGF-I overexpression, we examined the ocular phenotype of IGF-II promoter-driven IGF-I transgenic mice. Despite 2.5-fold elevation of IGF-I mRNA in the retina and 29 and 52% increase of IGF-I protein in the retina and aqueous humor, respectively, no ocular abnormality was observed in these transgenics. This was correlated with unaltered VEGF mRNA levels in the transgenic retina. The transgene was also associated with an attenuated laser-induced choroidal neovascularization. Differential expression levels and pattern of IGF-I gene may underlie the different retinal phenotypes in different transgenic lines.

Original languageEnglish (US)
Pages (from-to)776-782
Number of pages7
JournalVision Research
Volume47
Issue number6
DOIs
StatePublished - Mar 1 2007

Keywords

  • Choroidal neovascularization
  • Insulin-like growth factor I
  • Transgenic mouse

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems

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