Lambert-eaton syndrome

Robert Pascuzzi, Y. I. Kim

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

LES is an autoimmune disorder of the neuromuscular junction in which autoantibodies directed against voltage-dependent Ca2+ channels block nerve-evoked Ca2+ entry at the motor nerve terminal. The pathogenic IgG is likely to produce a similar inhibitory effect on the Ca2+ channel function in other cholinergic synapses of the autonomic nervous system. This pathophysiology is sufficient to account for the distinctive clinical, immunologic, and electrophysiologic manifestations in patients with LES. Etiology of this disease is uncertain but in view of its frequent association with small cell lung cancer, this specific type of neoplasm may be implicated in the initiation of auto-immune response. Recent studies indeed support the possibility that the antigenic stimulus in the neoplastic form of LES may arise from voltage-dependent Ca2+ channels found in the lung cancer cells.

Original languageEnglish
Pages (from-to)35-41
Number of pages7
JournalSeminars in Neurology
Volume10
Issue number1
StatePublished - 1990

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Neuromuscular Junction Diseases
Lambert-Eaton Myasthenic Syndrome
Nerve Block
Autonomic Nervous System
Small Cell Lung Carcinoma
Autoantibodies
Synapses
Cholinergic Agents
Lung Neoplasms
Immunoglobulin G
Neoplasms

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Pascuzzi, R., & Kim, Y. I. (1990). Lambert-eaton syndrome. Seminars in Neurology, 10(1), 35-41.

Lambert-eaton syndrome. / Pascuzzi, Robert; Kim, Y. I.

In: Seminars in Neurology, Vol. 10, No. 1, 1990, p. 35-41.

Research output: Contribution to journalArticle

Pascuzzi, R & Kim, YI 1990, 'Lambert-eaton syndrome', Seminars in Neurology, vol. 10, no. 1, pp. 35-41.
Pascuzzi, Robert ; Kim, Y. I. / Lambert-eaton syndrome. In: Seminars in Neurology. 1990 ; Vol. 10, No. 1. pp. 35-41.
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