Laser-plasma generated very high energy electrons in radiation therapy of the prostate

Colleen DesRosiers, Vadim Moskvin, Minsong Cao, Chandrashekhar J. Joshi, Mark Langer

Research output: Chapter in Book/Report/Conference proceedingConference contribution

13 Citations (Scopus)

Abstract

Monte Carlo simulation experiments have shown that very high energy electrons (VHEE), 150-250 MeV, have potential advantages in prostate cancer treatment over currently available electrons, photon and proton beam treatment. Small diameter VHEE beamlets can be scanned, thereby producing a finer resolution intensity modulated treatment than photon beams. VHEE beams may be delivered with greater precision and accelerators may be constructed at significantly lower cost than proton beams. A VHEE accelerator may be optimally designed using laser-plasma technology. If the accelerator is constructed to additionally produce low energy photon beams along with VHEE, real time imaging, bioprobing, and dose enhancement may be performed simultaneously. This paper describes a Monte Carlo experiment, using the parameters of the electron beam from the UCLA laser-plasma wakefield accelerator, whereby dose distributions on a human prostate are generated. The resulting dose distributions of the very high energy electrons are shown to be comparable to photon beam dose distributions. This simple experiment illustrates that the nature of the dose distribution of electrons is comparable to that of photons. However, the main advantage of electrons over photons and protons lies in the delivery and manipulation of electrons, rather than the nature of the dose distribution. This paper describes the radiation dose delivery of electrons employing technologies currently in exploration and evaluates potential benefits as compared with currently available photon and protons beams in the treatment of prostate and other cancers, commonly treated with radiation.

Original languageEnglish
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
Volume6881
DOIs
StatePublished - 2008
EventCommercial and Biomedical Applications of Ultrafast Lasers VIII - San Jose, CA, United States
Duration: Jan 20 2008Jan 23 2008

Other

OtherCommercial and Biomedical Applications of Ultrafast Lasers VIII
CountryUnited States
CitySan Jose, CA
Period1/20/081/23/08

Fingerprint

Radiotherapy
laser plasmas
high energy electrons
radiation therapy
photon beams
Plasmas
dosage
Photons
Electrons
Lasers
proton beams
Proton beams
electron beams
Dosimetry
Particle accelerators
delivery
accelerators
electrons
cancer
Electron beams

Keywords

  • Conformal radiotherapy
  • Laser-plasma
  • Monte Carlo
  • Particle therapy
  • PENELOPE
  • Prostate radiotherapy
  • Very high energy electrons

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

DesRosiers, C., Moskvin, V., Cao, M., Joshi, C. J., & Langer, M. (2008). Laser-plasma generated very high energy electrons in radiation therapy of the prostate. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 6881). [688109] https://doi.org/10.1117/12.761663

Laser-plasma generated very high energy electrons in radiation therapy of the prostate. / DesRosiers, Colleen; Moskvin, Vadim; Cao, Minsong; Joshi, Chandrashekhar J.; Langer, Mark.

Proceedings of SPIE - The International Society for Optical Engineering. Vol. 6881 2008. 688109.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

DesRosiers, C, Moskvin, V, Cao, M, Joshi, CJ & Langer, M 2008, Laser-plasma generated very high energy electrons in radiation therapy of the prostate. in Proceedings of SPIE - The International Society for Optical Engineering. vol. 6881, 688109, Commercial and Biomedical Applications of Ultrafast Lasers VIII, San Jose, CA, United States, 1/20/08. https://doi.org/10.1117/12.761663
DesRosiers C, Moskvin V, Cao M, Joshi CJ, Langer M. Laser-plasma generated very high energy electrons in radiation therapy of the prostate. In Proceedings of SPIE - The International Society for Optical Engineering. Vol. 6881. 2008. 688109 https://doi.org/10.1117/12.761663
DesRosiers, Colleen ; Moskvin, Vadim ; Cao, Minsong ; Joshi, Chandrashekhar J. ; Langer, Mark. / Laser-plasma generated very high energy electrons in radiation therapy of the prostate. Proceedings of SPIE - The International Society for Optical Engineering. Vol. 6881 2008.
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