Laser-plasma generated very high energy electrons in radiation therapy of the prostate

Colleen DesRosiers, Vadim Moskvin, Minsong Cao, Chandrashekhar J. Joshi, Mark Langer

Research output: Chapter in Book/Report/Conference proceedingConference contribution

14 Scopus citations

Abstract

Monte Carlo simulation experiments have shown that very high energy electrons (VHEE), 150-250 MeV, have potential advantages in prostate cancer treatment over currently available electrons, photon and proton beam treatment. Small diameter VHEE beamlets can be scanned, thereby producing a finer resolution intensity modulated treatment than photon beams. VHEE beams may be delivered with greater precision and accelerators may be constructed at significantly lower cost than proton beams. A VHEE accelerator may be optimally designed using laser-plasma technology. If the accelerator is constructed to additionally produce low energy photon beams along with VHEE, real time imaging, bioprobing, and dose enhancement may be performed simultaneously. This paper describes a Monte Carlo experiment, using the parameters of the electron beam from the UCLA laser-plasma wakefield accelerator, whereby dose distributions on a human prostate are generated. The resulting dose distributions of the very high energy electrons are shown to be comparable to photon beam dose distributions. This simple experiment illustrates that the nature of the dose distribution of electrons is comparable to that of photons. However, the main advantage of electrons over photons and protons lies in the delivery and manipulation of electrons, rather than the nature of the dose distribution. This paper describes the radiation dose delivery of electrons employing technologies currently in exploration and evaluates potential benefits as compared with currently available photon and protons beams in the treatment of prostate and other cancers, commonly treated with radiation.

Original languageEnglish (US)
Title of host publicationCommercial and Biomedical Applications of Ultrafast Lasers VIII
DOIs
StatePublished - Mar 31 2008
EventCommercial and Biomedical Applications of Ultrafast Lasers VIII - San Jose, CA, United States
Duration: Jan 20 2008Jan 23 2008

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
Volume6881
ISSN (Print)0277-786X

Other

OtherCommercial and Biomedical Applications of Ultrafast Lasers VIII
CountryUnited States
CitySan Jose, CA
Period1/20/081/23/08

Keywords

  • Conformal radiotherapy
  • Laser-plasma
  • Monte Carlo
  • Particle therapy
  • PENELOPE
  • Prostate radiotherapy
  • Very high energy electrons

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

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  • Cite this

    DesRosiers, C., Moskvin, V., Cao, M., Joshi, C. J., & Langer, M. (2008). Laser-plasma generated very high energy electrons in radiation therapy of the prostate. In Commercial and Biomedical Applications of Ultrafast Lasers VIII [688109] (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 6881). https://doi.org/10.1117/12.761663