Late growth of infantile hemangiomas in children >3 years of age

A retrospective study

Kathleen F. O'Brien, Sonal D. Shah, Elena Pope, Roderic J. Phillips, Francine Blei, Eulalia Baselga, Maria C. Garzon, Catherine McCuaig, Anita Haggstrom, Peter H. Hoeger, James R. Treat, Marissa J. Perman, Jane S. Bellet, Xavier Cubiró, Jeffrey Poole, Ilona J. Frieden

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: The proliferative phase of infantile hemangiomas (IHs) is usually complete by 9 months of life. Late growth beyond age 3 years is rarely reported. Objective: To describe the demographic and clinic characteristics of a cohort of patients with late growth of IH, defined as growth in a patient >3 years of age. Methods: A multicenter, retrospective cohort study. Results: In total, 59 patients, 85% of which were female, met the inclusion criteria. The mean first episode of late growth was 4.3 (range 3-8.5) years. Head and neck location (55/59; 93%) and presence of deep hemangioma (52/59; 88%) were common characteristics. Posterior fossa malformations, hemangiomas, arterial anomalies, cardiac defects, eye abnormalities (PHACE) syndrome was noted in 20 of 38 (53%) children with segmental facial IH. Systemic therapy (corticosteroid or β-blocker) was given during infancy in 58 of 59 (98%) and 24 of 59 (41%) received systemic therapy (β-blockers) for late IH growth. Limitations: The retrospective nature and ascertainment by investigator recall are limitations of the study. Conclusion: Late IH growth can occur in children after 3 years of age. Risk factors include head and neck location, segmental morphology, and involvement of deep dermal/subcutaneous tissues.

Original languageEnglish (US)
JournalJournal of the American Academy of Dermatology
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Hemangioma
Retrospective Studies
Growth
Neck
Head
Eye Abnormalities
Subcutaneous Tissue
Adrenal Cortex Hormones
Cohort Studies
Research Personnel
Demography
Skin
Therapeutics

Keywords

  • corticosteroid
  • growth hormone
  • infantile hemangioma
  • late growth
  • segmental morphology
  • β-blocker

ASJC Scopus subject areas

  • Dermatology

Cite this

O'Brien, K. F., Shah, S. D., Pope, E., Phillips, R. J., Blei, F., Baselga, E., ... Frieden, I. J. (Accepted/In press). Late growth of infantile hemangiomas in children >3 years of age: A retrospective study. Journal of the American Academy of Dermatology. https://doi.org/10.1016/j.jaad.2018.07.061

Late growth of infantile hemangiomas in children >3 years of age : A retrospective study. / O'Brien, Kathleen F.; Shah, Sonal D.; Pope, Elena; Phillips, Roderic J.; Blei, Francine; Baselga, Eulalia; Garzon, Maria C.; McCuaig, Catherine; Haggstrom, Anita; Hoeger, Peter H.; Treat, James R.; Perman, Marissa J.; Bellet, Jane S.; Cubiró, Xavier; Poole, Jeffrey; Frieden, Ilona J.

In: Journal of the American Academy of Dermatology, 01.01.2018.

Research output: Contribution to journalArticle

O'Brien, KF, Shah, SD, Pope, E, Phillips, RJ, Blei, F, Baselga, E, Garzon, MC, McCuaig, C, Haggstrom, A, Hoeger, PH, Treat, JR, Perman, MJ, Bellet, JS, Cubiró, X, Poole, J & Frieden, IJ 2018, 'Late growth of infantile hemangiomas in children >3 years of age: A retrospective study', Journal of the American Academy of Dermatology. https://doi.org/10.1016/j.jaad.2018.07.061
O'Brien, Kathleen F. ; Shah, Sonal D. ; Pope, Elena ; Phillips, Roderic J. ; Blei, Francine ; Baselga, Eulalia ; Garzon, Maria C. ; McCuaig, Catherine ; Haggstrom, Anita ; Hoeger, Peter H. ; Treat, James R. ; Perman, Marissa J. ; Bellet, Jane S. ; Cubiró, Xavier ; Poole, Jeffrey ; Frieden, Ilona J. / Late growth of infantile hemangiomas in children >3 years of age : A retrospective study. In: Journal of the American Academy of Dermatology. 2018.
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abstract = "Background: The proliferative phase of infantile hemangiomas (IHs) is usually complete by 9 months of life. Late growth beyond age 3 years is rarely reported. Objective: To describe the demographic and clinic characteristics of a cohort of patients with late growth of IH, defined as growth in a patient >3 years of age. Methods: A multicenter, retrospective cohort study. Results: In total, 59 patients, 85{\%} of which were female, met the inclusion criteria. The mean first episode of late growth was 4.3 (range 3-8.5) years. Head and neck location (55/59; 93{\%}) and presence of deep hemangioma (52/59; 88{\%}) were common characteristics. Posterior fossa malformations, hemangiomas, arterial anomalies, cardiac defects, eye abnormalities (PHACE) syndrome was noted in 20 of 38 (53{\%}) children with segmental facial IH. Systemic therapy (corticosteroid or β-blocker) was given during infancy in 58 of 59 (98{\%}) and 24 of 59 (41{\%}) received systemic therapy (β-blockers) for late IH growth. Limitations: The retrospective nature and ascertainment by investigator recall are limitations of the study. Conclusion: Late IH growth can occur in children after 3 years of age. Risk factors include head and neck location, segmental morphology, and involvement of deep dermal/subcutaneous tissues.",
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T2 - A retrospective study

AU - O'Brien, Kathleen F.

AU - Shah, Sonal D.

AU - Pope, Elena

AU - Phillips, Roderic J.

AU - Blei, Francine

AU - Baselga, Eulalia

AU - Garzon, Maria C.

AU - McCuaig, Catherine

AU - Haggstrom, Anita

AU - Hoeger, Peter H.

AU - Treat, James R.

AU - Perman, Marissa J.

AU - Bellet, Jane S.

AU - Cubiró, Xavier

AU - Poole, Jeffrey

AU - Frieden, Ilona J.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Background: The proliferative phase of infantile hemangiomas (IHs) is usually complete by 9 months of life. Late growth beyond age 3 years is rarely reported. Objective: To describe the demographic and clinic characteristics of a cohort of patients with late growth of IH, defined as growth in a patient >3 years of age. Methods: A multicenter, retrospective cohort study. Results: In total, 59 patients, 85% of which were female, met the inclusion criteria. The mean first episode of late growth was 4.3 (range 3-8.5) years. Head and neck location (55/59; 93%) and presence of deep hemangioma (52/59; 88%) were common characteristics. Posterior fossa malformations, hemangiomas, arterial anomalies, cardiac defects, eye abnormalities (PHACE) syndrome was noted in 20 of 38 (53%) children with segmental facial IH. Systemic therapy (corticosteroid or β-blocker) was given during infancy in 58 of 59 (98%) and 24 of 59 (41%) received systemic therapy (β-blockers) for late IH growth. Limitations: The retrospective nature and ascertainment by investigator recall are limitations of the study. Conclusion: Late IH growth can occur in children after 3 years of age. Risk factors include head and neck location, segmental morphology, and involvement of deep dermal/subcutaneous tissues.

AB - Background: The proliferative phase of infantile hemangiomas (IHs) is usually complete by 9 months of life. Late growth beyond age 3 years is rarely reported. Objective: To describe the demographic and clinic characteristics of a cohort of patients with late growth of IH, defined as growth in a patient >3 years of age. Methods: A multicenter, retrospective cohort study. Results: In total, 59 patients, 85% of which were female, met the inclusion criteria. The mean first episode of late growth was 4.3 (range 3-8.5) years. Head and neck location (55/59; 93%) and presence of deep hemangioma (52/59; 88%) were common characteristics. Posterior fossa malformations, hemangiomas, arterial anomalies, cardiac defects, eye abnormalities (PHACE) syndrome was noted in 20 of 38 (53%) children with segmental facial IH. Systemic therapy (corticosteroid or β-blocker) was given during infancy in 58 of 59 (98%) and 24 of 59 (41%) received systemic therapy (β-blockers) for late IH growth. Limitations: The retrospective nature and ascertainment by investigator recall are limitations of the study. Conclusion: Late IH growth can occur in children after 3 years of age. Risk factors include head and neck location, segmental morphology, and involvement of deep dermal/subcutaneous tissues.

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