Late growth of infantile hemangiomas in children >3 years of age: A retrospective study

Kathleen F. O'Brien, Sonal D. Shah, Elena Pope, Roderic J. Phillips, Francine Blei, Eulalia Baselga, Maria C. Garzon, Catherine McCuaig, Anita N. Haggstrom, Peter H. Hoeger, James R. Treat, Marissa J. Perman, Jane S. Bellet, Xavier Cubiró, Jeffrey Poole, Ilona J. Frieden

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1 Scopus citations


Background: The proliferative phase of infantile hemangiomas (IHs) is usually complete by 9 months of life. Late growth beyond age 3 years is rarely reported. Objective: To describe the demographic and clinic characteristics of a cohort of patients with late growth of IH, defined as growth in a patient >3 years of age. Methods: A multicenter, retrospective cohort study. Results: In total, 59 patients, 85% of which were female, met the inclusion criteria. The mean first episode of late growth was 4.3 (range 3-8.5) years. Head and neck location (55/59; 93%) and presence of deep hemangioma (52/59; 88%) were common characteristics. Posterior fossa malformations, hemangiomas, arterial anomalies, cardiac defects, eye abnormalities (PHACE) syndrome was noted in 20 of 38 (53%) children with segmental facial IH. Systemic therapy (corticosteroid or β-blocker) was given during infancy in 58 of 59 (98%) and 24 of 59 (41%) received systemic therapy (β-blockers) for late IH growth. Limitations: The retrospective nature and ascertainment by investigator recall are limitations of the study. Conclusion: Late IH growth can occur in children after 3 years of age. Risk factors include head and neck location, segmental morphology, and involvement of deep dermal/subcutaneous tissues.

Original languageEnglish (US)
Pages (from-to)493-499
Number of pages7
JournalJournal of the American Academy of Dermatology
Issue number2
StatePublished - Feb 2019


  • corticosteroid
  • growth hormone
  • infantile hemangioma
  • late growth
  • segmental morphology
  • β-blocker

ASJC Scopus subject areas

  • Dermatology

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    O'Brien, K. F., Shah, S. D., Pope, E., Phillips, R. J., Blei, F., Baselga, E., Garzon, M. C., McCuaig, C., Haggstrom, A. N., Hoeger, P. H., Treat, J. R., Perman, M. J., Bellet, J. S., Cubiró, X., Poole, J., & Frieden, I. J. (2019). Late growth of infantile hemangiomas in children >3 years of age: A retrospective study. Journal of the American Academy of Dermatology, 80(2), 493-499.