Latent coagulation disorders evaluated by the assay of plasma thrombin-antithrombin III complexes in a large series of 'solid tumours'

Carlo Bartoloni, Luisa Guidi, Augusto Tricerri, Francesca Patriarca, Roberto Pili, Flavio Cursi, Mattia Canetta, Alessandra Cappelli, Marcello Vangeli, Franco Salvati, Gino Gambassi

Research output: Contribution to journalArticle

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Abstract

Coagulation disorders are frequently detected in patients affected by different tumours even though clinical symptoms occur in a very small percentage of such subjects. Coagulation processes are probably involved in the mechanism of metastatic spread. We assayed the plasma levels of thrombin-antithrombin III (TAT) complexes in a group of 276 patients with several tumours in different stages in order to achieve a better understanding of the complex interactions between coagulation disorders and either tumour growth or metastatic spread. High levels of TAT complexes were found in 51 % of localized, 66.3% of metastatic and 58.3% of patients with no evidence of disease; a statistically significant difference was observed comparing metastatic cancer either with localized (p < 0.00015) or with free-of-disease (p < 0.004) groups. Gastrointestinal tract neoplasms showed higher levels of TAT complexes in the metastatic than in the localized group. No difference was seen between small-cell and non-small-cell lung-localized cancer. Our results confirm the frequent coexistence of cancer and subclinical blood coagulation disorders. The evidence of higher levels of TAT complexes in metastatic cancer than in the other groups could be related to the mechanisms involved in tumour spread.

Original languageEnglish (US)
Pages (from-to)426-430
Number of pages5
JournalOncology
Volume49
Issue number6
DOIs
StatePublished - 1992
Externally publishedYes

Fingerprint

Neoplasms
Blood Coagulation Disorders
Gastrointestinal Neoplasms
antithrombin III-protease complex
Non-Small Cell Lung Carcinoma
Gastrointestinal Tract
Growth

Keywords

  • Antithrombin III
  • Coagulation
  • Metastasis
  • Thrombin-antithrombin III complexes
  • Tumour

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Latent coagulation disorders evaluated by the assay of plasma thrombin-antithrombin III complexes in a large series of 'solid tumours'. / Bartoloni, Carlo; Guidi, Luisa; Tricerri, Augusto; Patriarca, Francesca; Pili, Roberto; Cursi, Flavio; Canetta, Mattia; Cappelli, Alessandra; Vangeli, Marcello; Salvati, Franco; Gambassi, Gino.

In: Oncology, Vol. 49, No. 6, 1992, p. 426-430.

Research output: Contribution to journalArticle

Bartoloni, C, Guidi, L, Tricerri, A, Patriarca, F, Pili, R, Cursi, F, Canetta, M, Cappelli, A, Vangeli, M, Salvati, F & Gambassi, G 1992, 'Latent coagulation disorders evaluated by the assay of plasma thrombin-antithrombin III complexes in a large series of 'solid tumours'', Oncology, vol. 49, no. 6, pp. 426-430. https://doi.org/10.1159/000227086
Bartoloni, Carlo ; Guidi, Luisa ; Tricerri, Augusto ; Patriarca, Francesca ; Pili, Roberto ; Cursi, Flavio ; Canetta, Mattia ; Cappelli, Alessandra ; Vangeli, Marcello ; Salvati, Franco ; Gambassi, Gino. / Latent coagulation disorders evaluated by the assay of plasma thrombin-antithrombin III complexes in a large series of 'solid tumours'. In: Oncology. 1992 ; Vol. 49, No. 6. pp. 426-430.
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