Lateral hypothalamic dynorphinergic efferents to the amygdala and brainstem in the rat

Andrea M. Zardetto-Smith, Margaret Moga, Debra J. Magnuson, Thackery S. Gray

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Dynorphin is present within perikarya of the lateral hypothalamus (LH) and perifornical nucleus (PeF), and within nerve terminals of the central nucleus of the amygdala, central grey, parabrachial nucleus, and the dorsal vagal complex (nucleus of the solitary tract and dorsal motor nucleus of the vagus). Each of these nuclei receive efferent projections from the LH and PeF. In this study, the possibility that dynorphin cells with LH and PeF innervate each of these nuclei was investigated using a combined retrograde tracing-immunofluorescence technique. As enkephalinergic perikarya have also been localized to LH and PeF, peptide E (an enkephalin precursor fragment) was also studied for comparison. Following injections of fast blue into the central nucleus, parabrachial nucleus, central grey, and dorsal vagal complex, numerous retrogradely-labeled dynorphin-immunoreactive neurons were present within the LH and PeF. In comparison, retrogradely-labeled peptide E-immunoreactive cells were infrequently observed. These results suggest the LH and PeF to be a major source of dynorphin to the forebrain and brainstem.

Original languageEnglish (US)
Pages (from-to)1121-1127
Number of pages7
JournalPeptides
Volume9
Issue number5
DOIs
StatePublished - 1988
Externally publishedYes

Fingerprint

Lateral Hypothalamic Area
Dynorphins
Amygdala
Brain Stem
Rats
Enkephalins
Neurons
Solitary Nucleus
Prosencephalon
Fluorescent Antibody Technique
Injections
peptide E (adrenal medulla)

Keywords

  • Amygdala
  • Brainstem
  • Dynorphin
  • Lateral hypothalamus
  • Rat

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Cellular and Molecular Neuroscience

Cite this

Lateral hypothalamic dynorphinergic efferents to the amygdala and brainstem in the rat. / Zardetto-Smith, Andrea M.; Moga, Margaret; Magnuson, Debra J.; Gray, Thackery S.

In: Peptides, Vol. 9, No. 5, 1988, p. 1121-1127.

Research output: Contribution to journalArticle

Zardetto-Smith, Andrea M. ; Moga, Margaret ; Magnuson, Debra J. ; Gray, Thackery S. / Lateral hypothalamic dynorphinergic efferents to the amygdala and brainstem in the rat. In: Peptides. 1988 ; Vol. 9, No. 5. pp. 1121-1127.
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