Lepirudin anticoagulation for heparin-induced thrombocytopenia after cardiac surgery in a pediatric patient

Chad A. Knoderer, Holly M. Knoderer, Mark W. Turrentine, Manjusha Kumar

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

A 21-month-old boy received anticoagulation with lepirudin for heparin-induced thrombocytopenia (HIT) after undergoing cardiac surgery and receiving extracorporeal membrane oxygenation (ECMO). This report illustrates the significance of HIT in pediatric patients after cardiac surgery and the successful administration of lepirudin in this setting. To our knowledge, this is the first published report of lepirudin administered to treat HIT in a child after cardiac surgery and ECMO. Although guidelines exist that suggest the potential administration of lepirudin as treatment for children with HIT, further studies are needed to determine the safest yet most effective dosage for this population.

Original languageEnglish (US)
Pages (from-to)709-712
Number of pages4
JournalPharmacotherapy
Volume26
Issue number5 I
DOIs
StatePublished - May 2006

Keywords

  • Anticoagulation
  • Heparin-induced thrombocytopenia
  • HIT
  • Lepirudin
  • Pediatric

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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