Abstract
A 21-month-old boy received anticoagulation with lepirudin for heparin-induced thrombocytopenia (HIT) after undergoing cardiac surgery and receiving extracorporeal membrane oxygenation (ECMO). This report illustrates the significance of HIT in pediatric patients after cardiac surgery and the successful administration of lepirudin in this setting. To our knowledge, this is the first published report of lepirudin administered to treat HIT in a child after cardiac surgery and ECMO. Although guidelines exist that suggest the potential administration of lepirudin as treatment for children with HIT, further studies are needed to determine the safest yet most effective dosage for this population.
| Original language | English |
|---|---|
| Pages (from-to) | 709-712 |
| Number of pages | 4 |
| Journal | Pharmacotherapy |
| Volume | 26 |
| Issue number | 5 I |
| State | Published - May 2006 |
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Keywords
- Anticoagulation
- Heparin-induced thrombocytopenia
- HIT
- Lepirudin
- Pediatric
ASJC Scopus subject areas
- Pharmacology (medical)
- Pharmacology, Toxicology and Pharmaceutics(all)
Cite this
Lepirudin anticoagulation for heparin-induced thrombocytopenia after cardiac surgery in a pediatric patient. / Knoderer, Chad A.; Knoderer, Holly M.; Turrentine, Mark; Kumar, Manjusha.
In: Pharmacotherapy, Vol. 26, No. 5 I, 05.2006, p. 709-712.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Lepirudin anticoagulation for heparin-induced thrombocytopenia after cardiac surgery in a pediatric patient
AU - Knoderer, Chad A.
AU - Knoderer, Holly M.
AU - Turrentine, Mark
AU - Kumar, Manjusha
PY - 2006/5
Y1 - 2006/5
N2 - A 21-month-old boy received anticoagulation with lepirudin for heparin-induced thrombocytopenia (HIT) after undergoing cardiac surgery and receiving extracorporeal membrane oxygenation (ECMO). This report illustrates the significance of HIT in pediatric patients after cardiac surgery and the successful administration of lepirudin in this setting. To our knowledge, this is the first published report of lepirudin administered to treat HIT in a child after cardiac surgery and ECMO. Although guidelines exist that suggest the potential administration of lepirudin as treatment for children with HIT, further studies are needed to determine the safest yet most effective dosage for this population.
AB - A 21-month-old boy received anticoagulation with lepirudin for heparin-induced thrombocytopenia (HIT) after undergoing cardiac surgery and receiving extracorporeal membrane oxygenation (ECMO). This report illustrates the significance of HIT in pediatric patients after cardiac surgery and the successful administration of lepirudin in this setting. To our knowledge, this is the first published report of lepirudin administered to treat HIT in a child after cardiac surgery and ECMO. Although guidelines exist that suggest the potential administration of lepirudin as treatment for children with HIT, further studies are needed to determine the safest yet most effective dosage for this population.
KW - Anticoagulation
KW - Heparin-induced thrombocytopenia
KW - HIT
KW - Lepirudin
KW - Pediatric
UR - http://www.scopus.com/inward/record.url?scp=33646383074&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33646383074&partnerID=8YFLogxK
M3 - Article
C2 - 16718945
AN - SCOPUS:33646383074
VL - 26
SP - 709
EP - 712
JO - Pharmacotherapy
JF - Pharmacotherapy
SN - 0277-0008
IS - 5 I
ER -