Lepirudin anticoagulation for heparin-induced thrombocytopenia after cardiac surgery in a pediatric patient

Chad A. Knoderer, Holly M. Knoderer, Mark Turrentine, Manjusha Kumar

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

A 21-month-old boy received anticoagulation with lepirudin for heparin-induced thrombocytopenia (HIT) after undergoing cardiac surgery and receiving extracorporeal membrane oxygenation (ECMO). This report illustrates the significance of HIT in pediatric patients after cardiac surgery and the successful administration of lepirudin in this setting. To our knowledge, this is the first published report of lepirudin administered to treat HIT in a child after cardiac surgery and ECMO. Although guidelines exist that suggest the potential administration of lepirudin as treatment for children with HIT, further studies are needed to determine the safest yet most effective dosage for this population.

Original languageEnglish
Pages (from-to)709-712
Number of pages4
JournalPharmacotherapy
Volume26
Issue number5 I
StatePublished - May 2006

Fingerprint

Thrombocytopenia
Thoracic Surgery
Heparin
Pediatrics
Extracorporeal Membrane Oxygenation
Guidelines
lepirudin
Population
Therapeutics

Keywords

  • Anticoagulation
  • Heparin-induced thrombocytopenia
  • HIT
  • Lepirudin
  • Pediatric

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Lepirudin anticoagulation for heparin-induced thrombocytopenia after cardiac surgery in a pediatric patient. / Knoderer, Chad A.; Knoderer, Holly M.; Turrentine, Mark; Kumar, Manjusha.

In: Pharmacotherapy, Vol. 26, No. 5 I, 05.2006, p. 709-712.

Research output: Contribution to journalArticle

Knoderer, Chad A. ; Knoderer, Holly M. ; Turrentine, Mark ; Kumar, Manjusha. / Lepirudin anticoagulation for heparin-induced thrombocytopenia after cardiac surgery in a pediatric patient. In: Pharmacotherapy. 2006 ; Vol. 26, No. 5 I. pp. 709-712.
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