Abstract
A 21-month-old boy received anticoagulation with lepirudin for heparin-induced thrombocytopenia (HIT) after undergoing cardiac surgery and receiving extracorporeal membrane oxygenation (ECMO). This report illustrates the significance of HIT in pediatric patients after cardiac surgery and the successful administration of lepirudin in this setting. To our knowledge, this is the first published report of lepirudin administered to treat HIT in a child after cardiac surgery and ECMO. Although guidelines exist that suggest the potential administration of lepirudin as treatment for children with HIT, further studies are needed to determine the safest yet most effective dosage for this population.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 709-712 |
| Number of pages | 4 |
| Journal | Pharmacotherapy |
| Volume | 26 |
| Issue number | 5 I |
| DOIs | |
| State | Published - May 2006 |
Keywords
- Anticoagulation
- Heparin-induced thrombocytopenia
- HIT
- Lepirudin
- Pediatric
ASJC Scopus subject areas
- Pharmacology (medical)
- Pharmacology, Toxicology and Pharmaceutics(all)
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Knoderer, C. A., Knoderer, H. M., Turrentine, M. W., & Kumar, M. (2006). Lepirudin anticoagulation for heparin-induced thrombocytopenia after cardiac surgery in a pediatric patient. Pharmacotherapy, 26(5 I), 709-712. https://doi.org/10.1592/phco.26.5.709