Rachel C. Morgan, Robert V. Considine

Research output: Chapter in Book/Report/Conference proceedingChapter


Leptin is a 16 kDa hormone synthesized and released by adipose tissue. The primary receptor for leptin is located in the central nervous system. Blood leptin levels increase in proportion to the amount of body fat, and are greater in women than men. Leptin inhibits food intake and reduces body fat in animal models, but is not an effective weight loss treatment in obese humans, who exhibit leptin resistance. Leptin regulates a number of physiological processes via the central nervous system and by direct actions on nonneural tissues including glucose homeostasis, lipid metabolism, immune function, bone metabolism and reproduction.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Endocrine Diseases
Number of pages8
ISBN (Electronic)9780128122006
ISBN (Print)9780128121993
StatePublished - Jan 1 2018


  • Adipocyte
  • Db/db mouse
  • Genetic mutation
  • Glucose
  • Hypothalamus
  • Insulin
  • Leptin
  • Leptin receptor
  • Leptin resistance
  • Lipodystrophy
  • Ob/ob mouse
  • Obesity
  • Sympathetic nervous system
  • Weight loss

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Morgan, R. C., & Considine, R. V. (2018). Leptin. In Encyclopedia of Endocrine Diseases (pp. 420-427). Elsevier. https://doi.org/10.1016/B978-0-12-801238-3.03843-5