Leptin and intermediary metabolism: Focus on glucoregulation and lipids

Rachel C. Morgan, Robert V. Considine

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


In the first studies of leptin administration to obese mice it was noted that low dose leptin, which did not alter food intake or body weight, decreased blood glucose. This observation initiated investigation into the mechanisms through which leptin regulated intermediary metabolism independent of effects on caloric intake and body weight. With leptin receptors present in the central nervous system and on peripheral tissues, metabolic effects of leptin can be mediated via activation of neural pathways in the brain or by direct binding to the major metabolic tissues including the liver, skeletal muscle, adipose tissue, and pancreas. Leptin regulation of glucose and lipid homeostasis has been observed in multiple rodent models and in humans with hypoleptinemic lipodystrophy. Understanding the mechanisms through which leptin regulates intermediary metabolism is anticipated to result in better therapeutic interventions to correct dysregulated metabolism in obesity and diabetes.

Original languageEnglish (US)
Title of host publicationLeptin
Subtitle of host publicationRegulation and Clinical Applications
PublisherSpringer International Publishing
Number of pages10
ISBN (Electronic)9783319099156
ISBN (Print)9783319099149
StatePublished - Jan 1 2015


  • Free fatty acids
  • Glucose
  • Insulin
  • Intermediary metabolism
  • Leptin
  • Leptin receptor
  • Sympathetic nervous system
  • Triglyceride

ASJC Scopus subject areas

  • Medicine(all)

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    Morgan, R. C., & Considine, R. V. (2015). Leptin and intermediary metabolism: Focus on glucoregulation and lipids. In Leptin: Regulation and Clinical Applications (pp. 79-88). Springer International Publishing. https://doi.org/10.1007/978-3-319-09915-6_7