Leptin and the regulation of body weight

Robert V. Considine, Jose F. Caro

Research output: Contribution to journalReview article

164 Scopus citations


Leptin has received considerable attention as a newly recognized metabolic hormone and for its potential for tharapeutic use in the treatment of human obesity, Furthermore, defects in the leptin signal pathway that result in obesity in animal models have raised the possibility of a similar etiology for obesity in humans. This review will summarize the current findings on leptin in both humans and rodents. These findings will be discussed with respect to our view of the physiology and potential for pathophysiology in leptin-mediated regulation of body weight and composition.

Original languageEnglish (US)
Pages (from-to)1255-1272
Number of pages18
JournalInternational Journal of Biochemistry and Cell Biology
Issue number11
StatePublished - Nov 1 1997
Externally publishedYes


  • Leptin
  • Leptin receptor
  • Ob gene
  • Obesity

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology

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