Leptin and the regulation of body weight

Robert Considine, Jose F. Caro

Research output: Contribution to journalArticle

160 Citations (Scopus)

Abstract

Leptin has received considerable attention as a newly recognized metabolic hormone and for its potential for tharapeutic use in the treatment of human obesity, Furthermore, defects in the leptin signal pathway that result in obesity in animal models have raised the possibility of a similar etiology for obesity in humans. This review will summarize the current findings on leptin in both humans and rodents. These findings will be discussed with respect to our view of the physiology and potential for pathophysiology in leptin-mediated regulation of body weight and composition.

Original languageEnglish (US)
Pages (from-to)1255-1272
Number of pages18
JournalInternational Journal of Biochemistry and Cell Biology
Volume29
Issue number11
DOIs
StatePublished - Nov 1997
Externally publishedYes

Fingerprint

Leptin
Body Weight
Obesity
Physiology
Body Composition
Rodentia
Signal Transduction
Animals
Animal Models
Hormones
Defects
Chemical analysis

Keywords

  • Leptin
  • Leptin receptor
  • Ob gene
  • Obesity

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology

Cite this

Leptin and the regulation of body weight. / Considine, Robert; Caro, Jose F.

In: International Journal of Biochemistry and Cell Biology, Vol. 29, No. 11, 11.1997, p. 1255-1272.

Research output: Contribution to journalArticle

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