Leptin levels in type 2 diabetes: Associations with measures of insulin resistance and insulin secretion

M. Wauters, Robert Considine, J. S. Yudkin, F. Peiffer, I. De Leeuw, L. F. Van Gaal

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

Interactions between leptin and insulin have been shown previously, in vitro and in vivo. In this study, we evaluate the associations of leptin levels with insulin secretion and insulin sensitivity in type 2 diabetes. Fasting leptin levels, HbA1c, glucose, insulin, C-peptide, intact and des-31,32-proinsulin were measured in 100 non-insulin-treated type 2 diabetic patients. Glucose, insulin and C-peptide were measured 2 hours after an oral glucose load. Insulin resistance and β-cell function were calculated using HOMA. Leptin levels were found to be associated with all measures of β-cell secretion: with fasting and 2 hours insulin and C-peptide, with intact and des-31,32-proinsulin concentrations, and with β-cell secretion estimated with HOMA. This association was independent of age and body fat in women, but in men, associations with insulin and C-peptide weakened after controlling for fat mass, whereas those with intact and des-31,32-proinsulin disappeared. Fasting insulin and C-peptide levels were also significant in multiple regression analyses, besides gender and fat mass. Insulin resistance, as assessed by HOMA, was strongly correlated with leptin, also after correction for age and fat mass in both genders. We conclude that, besides fat mass and gender -the main determinants for leptin levels in type 2 diabetic subjects as in healthy subjects - insulin secretion and the degree of insulin resistance also seem to contribute significantly to leptin levels.

Original languageEnglish
Pages (from-to)92-96
Number of pages5
JournalHormone and Metabolic Research
Volume35
Issue number2
DOIs
StatePublished - Feb 1 2003

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Medical problems
Leptin
Type 2 Diabetes Mellitus
Insulin Resistance
C-Peptide
Insulin
Fats
Fasting
Glucose
Adipose Tissue
Healthy Volunteers
Regression Analysis
des(31,32)-proinsulin

Keywords

  • β-Cell Function
  • Insulin Resistance
  • Leptin
  • Proinsulin
  • Type 2 Diabetes

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

Cite this

Leptin levels in type 2 diabetes : Associations with measures of insulin resistance and insulin secretion. / Wauters, M.; Considine, Robert; Yudkin, J. S.; Peiffer, F.; De Leeuw, I.; Van Gaal, L. F.

In: Hormone and Metabolic Research, Vol. 35, No. 2, 01.02.2003, p. 92-96.

Research output: Contribution to journalArticle

Wauters, M. ; Considine, Robert ; Yudkin, J. S. ; Peiffer, F. ; De Leeuw, I. ; Van Gaal, L. F. / Leptin levels in type 2 diabetes : Associations with measures of insulin resistance and insulin secretion. In: Hormone and Metabolic Research. 2003 ; Vol. 35, No. 2. pp. 92-96.
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