Less cholesterol means better tumor killing for cytotoxic T9 cells

Brad Griesenauer, Sophie Paczesny

Research output: Contribution to journalComment/debate

Abstract

In this issue, Ma et al. (https://doi.org/10.1084/jem.20171576) show that removal of cholesterol from CD8 T cells during type 9 differentiation increases their IL-9 production, persistence in vivo, and cytolytic function against tumors by preventing SUMOylation of liver X receptors.

Original languageEnglish (US)
Pages (from-to)1505-1506
Number of pages2
JournalThe Journal of experimental medicine
Volume215
Issue number6
DOIs
StatePublished - Jun 4 2018

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Interleukin-9
Sumoylation
Cholesterol
T-Lymphocytes
Neoplasms
Liver X Receptors

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Less cholesterol means better tumor killing for cytotoxic T9 cells. / Griesenauer, Brad; Paczesny, Sophie.

In: The Journal of experimental medicine, Vol. 215, No. 6, 04.06.2018, p. 1505-1506.

Research output: Contribution to journalComment/debate

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