Lessons learned in human tissue banking for acquiring high quality biospecimens for translational genomic research: A perspective of the iu simon cancer center tissue/fluid biobank

George Sandusky, Stacey B. Sandusky, Liang Cheng

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

For the past 11 years, fresh frozen and paraffin embedded human normal and tumor tissues have been banked in a collaborative effort between various clinical departments including surgery, pathology and clinical oncology in the Indiana University Simon Cancer Center in order to study the translational relationship between genes and proteins which are altered in various types of neoplasms and compared to translational expression in normal human tissues.This review is a compilation of the work between several departments within the School of Medicine, from IRB protocol approval, patient informed consent document, and HIPAA consent sign off process, frozen tissue collection, both frozen and fixed tissue sample processing, storage of the tissue, and database tracking of the specimens as they are sent to the researchers. This review highlights the banking processes as well as the quality control of the tissues and the lessons learned in the tissue bank process over the past 11 years as it relates to using high quality biospecimens for translational genomic research. High quality biospecimens is the key for best practices in all translational genomic and proteomic research. The success of genomic research and its application in both the clinical and basic research for translational medicine and drug discovery is strongly dependent on the best practices for collection, handling, and storage of human tissue samples for research' (Farkas, Kaul et al. 1996), (Naber 1996)( Holland et al).

Original languageEnglish (US)
Title of host publicationThe Human Genome
Subtitle of host publicationFeatures, Variations and Genetic Disorders
PublisherNova Science Publishers, Inc.
Pages277-293
Number of pages17
ISBN (Electronic)9781617285936
ISBN (Print)9781607416951
StatePublished - Jan 1 2009

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Sandusky, G., Sandusky, S. B., & Cheng, L. (2009). Lessons learned in human tissue banking for acquiring high quality biospecimens for translational genomic research: A perspective of the iu simon cancer center tissue/fluid biobank. In The Human Genome: Features, Variations and Genetic Disorders (pp. 277-293). Nova Science Publishers, Inc..