Leukemia and chromosomal instability in aged Fancc-/- mice

Donna Cerabona, Zejin Sun, Grzegorz Nalepa

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Fanconi anemia (FA) is an inherited disorder of genomic instability associated with high risk of myelodysplasia and acute myeloid leukemia (AML). Young mice deficient in FA core complex genes do not naturally develop cancer, hampering preclinical studies on malignant hematopoiesis in FA. Here we describe that aging Fancc-/- mice are prone to genomically unstable AML and other hematologic neoplasms. We report that aneuploidy precedes malignant transformation during Fancc-/- hematopoiesis. Our observations reveal that Fancc-/- mice develop hematopoietic chromosomal instability followed by leukemia in an age-dependent manner, recapitulating the clinical phenotype of human FA and providing a proof of concept for future development of preclinical models of FA-associated leukemogenesis.

Original languageEnglish (US)
Pages (from-to)352-357
Number of pages6
JournalExperimental Hematology
Volume44
Issue number5
DOIs
StatePublished - May 1 2016

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ASJC Scopus subject areas

  • Medicine(all)
  • Molecular Biology
  • Hematology
  • Genetics
  • Cell Biology
  • Cancer Research

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