Leuko-araiosis: description and clinical correlates.

R. R. Smith, H. C. Hendrie

Research output: Contribution to journalArticle

5 Scopus citations


The term leuko-araiosis as predicted by Hachinski may now have outlived its usefulness. Careful delineation of the white matter changes seen in MR imaging by use of the MR characteristics and by the location of the lesions may reduce the apparent heterogeneity of the associate clinical and neuropathological findings. As currently defined, leuko-araiosis is seen in aggregate more commonly in subjects with cerebro-vascular disease or with cerebro-vascular risk factors but it is a common finding associated with aging in otherwise normal, healthy elderly subjects. Its clinical significance as an isolated finding in these populations should therefore be treated cautiously. Its appearance should alert the physician however to seek for and treat potential cerebro-vascular risk factors.

Original languageEnglish (US)
Pages (from-to)7-16
Number of pages10
JournalComprehensive Therapy
Issue number1
StatePublished - Jan 1 1992

ASJC Scopus subject areas

  • Medicine(all)

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