Like father, like son: Periventricular nodular heterotopia and nonverbal learning disorder

Marcia V. McCann, Stephen J. Pongonis, Meredith R. Golomb, Mary Edwards-Brown, Celanie K. Christensen, Deborah K. Sokol

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Periventricular nodular heterotopia is a common malformation of cortical development in which the migration of developing neurons destined for the cerebral cortex is abbreviated. Bilateral periventricular nodular heterotopia is most commonly an X-linked disorder that involves mutations in the filamin A (FLNA) gene, but an autosomal recessive form and sporadic forms have been identified. To our knowledge, autosomal dominant transmission of isolated periventricular nodular heterotopia has not been reported. Periventricular nodular heterotopia has a heterogeneous phenotype, associated commonly with seizure disorder, and more recently with reading deficits and visual-spatial deficits in some patients. We present a father and son with bilateral periventricular nodular heterotopia and similar visual-spatial learning deficits, consistent with nonverbal learning disability.

Original languageEnglish (US)
Pages (from-to)950-953
Number of pages4
JournalJournal of Child Neurology
Volume23
Issue number8
DOIs
StatePublished - Aug 1 2008

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Keywords

  • Nonverbal learning disability
  • Periventricular nodular heterotopia
  • Visual-spatial deficits

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health

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