Like father, like son: Periventricular nodular heterotopia and nonverbal learning disorder

Marcia Felker, Stephen J. Pongonis, Meredith Golomb, Mary Edwards-Brown, Celanie K. Christensen, Deborah Sokol

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Periventricular nodular heterotopia is a common malformation of cortical development in which the migration of developing neurons destined for the cerebral cortex is abbreviated. Bilateral periventricular nodular heterotopia is most commonly an X-linked disorder that involves mutations in the filamin A (FLNA) gene, but an autosomal recessive form and sporadic forms have been identified. To our knowledge, autosomal dominant transmission of isolated periventricular nodular heterotopia has not been reported. Periventricular nodular heterotopia has a heterogeneous phenotype, associated commonly with seizure disorder, and more recently with reading deficits and visual-spatial deficits in some patients. We present a father and son with bilateral periventricular nodular heterotopia and similar visual-spatial learning deficits, consistent with nonverbal learning disability.

Original languageEnglish
Pages (from-to)950-953
Number of pages4
JournalJournal of Child Neurology
Volume23
Issue number8
DOIs
StatePublished - Aug 2008

Fingerprint

Periventricular Nodular Heterotopia
Learning Disorders
Filamins
Recessive Genes
Malformations of Cortical Development
Nuclear Family
Fathers
Cerebral Cortex
Reading
Epilepsy
Phenotype
Neurons
Mutation

Keywords

  • Nonverbal learning disability
  • Periventricular nodular heterotopia
  • Visual-spatial deficits

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health

Cite this

Like father, like son : Periventricular nodular heterotopia and nonverbal learning disorder. / Felker, Marcia; Pongonis, Stephen J.; Golomb, Meredith; Edwards-Brown, Mary; Christensen, Celanie K.; Sokol, Deborah.

In: Journal of Child Neurology, Vol. 23, No. 8, 08.2008, p. 950-953.

Research output: Contribution to journalArticle

Felker, Marcia ; Pongonis, Stephen J. ; Golomb, Meredith ; Edwards-Brown, Mary ; Christensen, Celanie K. ; Sokol, Deborah. / Like father, like son : Periventricular nodular heterotopia and nonverbal learning disorder. In: Journal of Child Neurology. 2008 ; Vol. 23, No. 8. pp. 950-953.
@article{21bfcce1af8e4d11a4871119fa02b9d0,
title = "Like father, like son: Periventricular nodular heterotopia and nonverbal learning disorder",
abstract = "Periventricular nodular heterotopia is a common malformation of cortical development in which the migration of developing neurons destined for the cerebral cortex is abbreviated. Bilateral periventricular nodular heterotopia is most commonly an X-linked disorder that involves mutations in the filamin A (FLNA) gene, but an autosomal recessive form and sporadic forms have been identified. To our knowledge, autosomal dominant transmission of isolated periventricular nodular heterotopia has not been reported. Periventricular nodular heterotopia has a heterogeneous phenotype, associated commonly with seizure disorder, and more recently with reading deficits and visual-spatial deficits in some patients. We present a father and son with bilateral periventricular nodular heterotopia and similar visual-spatial learning deficits, consistent with nonverbal learning disability.",
keywords = "Nonverbal learning disability, Periventricular nodular heterotopia, Visual-spatial deficits",
author = "Marcia Felker and Pongonis, {Stephen J.} and Meredith Golomb and Mary Edwards-Brown and Christensen, {Celanie K.} and Deborah Sokol",
year = "2008",
month = "8",
doi = "10.1177/0883073808315415",
language = "English",
volume = "23",
pages = "950--953",
journal = "Journal of Child Neurology",
issn = "0883-0738",
publisher = "SAGE Publications Inc.",
number = "8",

}

TY - JOUR

T1 - Like father, like son

T2 - Periventricular nodular heterotopia and nonverbal learning disorder

AU - Felker, Marcia

AU - Pongonis, Stephen J.

AU - Golomb, Meredith

AU - Edwards-Brown, Mary

AU - Christensen, Celanie K.

AU - Sokol, Deborah

PY - 2008/8

Y1 - 2008/8

N2 - Periventricular nodular heterotopia is a common malformation of cortical development in which the migration of developing neurons destined for the cerebral cortex is abbreviated. Bilateral periventricular nodular heterotopia is most commonly an X-linked disorder that involves mutations in the filamin A (FLNA) gene, but an autosomal recessive form and sporadic forms have been identified. To our knowledge, autosomal dominant transmission of isolated periventricular nodular heterotopia has not been reported. Periventricular nodular heterotopia has a heterogeneous phenotype, associated commonly with seizure disorder, and more recently with reading deficits and visual-spatial deficits in some patients. We present a father and son with bilateral periventricular nodular heterotopia and similar visual-spatial learning deficits, consistent with nonverbal learning disability.

AB - Periventricular nodular heterotopia is a common malformation of cortical development in which the migration of developing neurons destined for the cerebral cortex is abbreviated. Bilateral periventricular nodular heterotopia is most commonly an X-linked disorder that involves mutations in the filamin A (FLNA) gene, but an autosomal recessive form and sporadic forms have been identified. To our knowledge, autosomal dominant transmission of isolated periventricular nodular heterotopia has not been reported. Periventricular nodular heterotopia has a heterogeneous phenotype, associated commonly with seizure disorder, and more recently with reading deficits and visual-spatial deficits in some patients. We present a father and son with bilateral periventricular nodular heterotopia and similar visual-spatial learning deficits, consistent with nonverbal learning disability.

KW - Nonverbal learning disability

KW - Periventricular nodular heterotopia

KW - Visual-spatial deficits

UR - http://www.scopus.com/inward/record.url?scp=48449095552&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=48449095552&partnerID=8YFLogxK

U2 - 10.1177/0883073808315415

DO - 10.1177/0883073808315415

M3 - Article

C2 - 18660478

AN - SCOPUS:48449095552

VL - 23

SP - 950

EP - 953

JO - Journal of Child Neurology

JF - Journal of Child Neurology

SN - 0883-0738

IS - 8

ER -