LIM-homeodomain genes in mammalian development and human disease

Chad S. Hunter, Simon Rhodes

Research output: Contribution to journalArticle

83 Citations (Scopus)

Abstract

The human and mouse genomes each contain at least 12 genes encoding LIM homeodomain (LIM-HD) transcription factors. These gene regulatory proteins feature two LIM domains in their amino termini and a characteristic DNA binding homeodomain. Studies of mouse models and human patients have established that the LIM-HD factors are critical for the development of specialized cells in multiple tissue types, including the nervous system, skeletal muscle, the heart, the kidneys, and endocrine organs such as the pituitary gland and the pancreas. In this article, we review the roles of the LIM-HD proteins in mammalian development and their involvement in human diseases.

Original languageEnglish
Pages (from-to)67-77
Number of pages11
JournalMolecular Biology Reports
Volume32
Issue number2
DOIs
StatePublished - Jun 2005

Fingerprint

Human Development
LIM-Homeodomain Proteins
Genes
Gene encoding
Neurology
Human Genome
Pituitary Gland
Nervous System
Muscle
Pancreas
Skeletal Muscle
Transcription Factors
Tissue
Kidney
DNA
Proteins

Keywords

  • Differentiation
  • Mouse
  • Rat
  • Transcription factor

ASJC Scopus subject areas

  • Genetics
  • Cell Biology
  • Biochemistry

Cite this

LIM-homeodomain genes in mammalian development and human disease. / Hunter, Chad S.; Rhodes, Simon.

In: Molecular Biology Reports, Vol. 32, No. 2, 06.2005, p. 67-77.

Research output: Contribution to journalArticle

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