Limb regeneration in amphibians: Immunological considerations

Anthony Mescher, Anton W. Neff

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

We review key aspects of what is known about limb regeneration in urodele and anuran amphibians, with a focus on the early events of the process that lead to formation of the regeneration blastema. This includes the role of the nerves and wound epithelium, but also covers the inflammatory effects of the amputation trauma and their importance for regenerative growth. We propose that immunotolerance is important for limb regeneration and changes in its regulation may underlie the loss of regenerative capacity during anuran metamorphosis.

Original languageEnglish
Pages (from-to)1-11
Number of pages11
JournalTheScientificWorldJournal
Volume6
Issue numberSUPPL.1
DOIs
StatePublished - Feb 26 2006

Fingerprint

Amphibians
amphibian
limb
Regeneration
Extremities
regeneration
Wounds and Injuries
metamorphosis
Amputation
Epithelium
Growth

Keywords

  • FGF
  • Fibroblast growth factor
  • Immunity
  • Immunotolerance
  • Inflammation
  • Limb
  • Nerves
  • Regeneration
  • Transferrin
  • Wound epithelium
  • Wound repair

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)
  • Medicine(all)

Cite this

Limb regeneration in amphibians : Immunological considerations. / Mescher, Anthony; Neff, Anton W.

In: TheScientificWorldJournal, Vol. 6, No. SUPPL.1, 26.02.2006, p. 1-11.

Research output: Contribution to journalArticle

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