Limb regeneration in amphibians: Immunological considerations

Anthony L. Mescher, Anton W. Neff

Research output: Contribution to journalReview articlepeer-review

53 Scopus citations


We review key aspects of what is known about limb regeneration in urodele and anuran amphibians, with a focus on the early events of the process that lead to formation of the regeneration blastema. This includes the role of the nerves and wound epithelium, but also covers the inflammatory effects of the amputation trauma and their importance for regenerative growth. We propose that immunotolerance is important for limb regeneration and changes in its regulation may underlie the loss of regenerative capacity during anuran metamorphosis.

Original languageEnglish (US)
Pages (from-to)1-11
Number of pages11
Issue numberSUPPL.1
StatePublished - Feb 26 2006


  • FGF
  • Fibroblast growth factor
  • Immunity
  • Immunotolerance
  • Inflammation
  • Limb
  • Nerves
  • Regeneration
  • Transferrin
  • Wound epithelium
  • Wound repair

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)
  • Medicine(all)

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