Limitation of excessive myelopoiesis by the intrinsic modulation of macrophage-derived prostaglandin E

Jeffrey I. Kurland, Richard S. Bockman, Hal Broxmeyer, Malcolm A S Moore

Research output: Contribution to journalArticle

163 Citations (Scopus)

Abstract

The clonal proliferation of the committed granulocyte-macrophage stem cell is controlled by a balance between mutually opposing factors, colony stimulating factor and prostaglandin E, both of monocyte-macrophage derivation. Increases beyond a critical concentration of colony stimulating factor within the local milieu of the mononuclear phagocyte induces the coincident elaboration of prostaglandin E, a self-regulated response which serves to limit the unopposed humoral stimulation of myelopoiesis.

Original languageEnglish (US)
Pages (from-to)552-555
Number of pages4
JournalScience
Volume199
Issue number4328
StatePublished - 1978
Externally publishedYes

Fingerprint

Myelopoiesis
Colony-Stimulating Factors
Prostaglandins E
Macrophages
Phagocytes
Granulocytes
Monocytes
Stem Cells

ASJC Scopus subject areas

  • General

Cite this

Limitation of excessive myelopoiesis by the intrinsic modulation of macrophage-derived prostaglandin E. / Kurland, Jeffrey I.; Bockman, Richard S.; Broxmeyer, Hal; Moore, Malcolm A S.

In: Science, Vol. 199, No. 4328, 1978, p. 552-555.

Research output: Contribution to journalArticle

Kurland, JI, Bockman, RS, Broxmeyer, H & Moore, MAS 1978, 'Limitation of excessive myelopoiesis by the intrinsic modulation of macrophage-derived prostaglandin E', Science, vol. 199, no. 4328, pp. 552-555.
Kurland, Jeffrey I. ; Bockman, Richard S. ; Broxmeyer, Hal ; Moore, Malcolm A S. / Limitation of excessive myelopoiesis by the intrinsic modulation of macrophage-derived prostaglandin E. In: Science. 1978 ; Vol. 199, No. 4328. pp. 552-555.
@article{b4b86d738d2a4fac8b75fd23c1d064fa,
title = "Limitation of excessive myelopoiesis by the intrinsic modulation of macrophage-derived prostaglandin E",
abstract = "The clonal proliferation of the committed granulocyte-macrophage stem cell is controlled by a balance between mutually opposing factors, colony stimulating factor and prostaglandin E, both of monocyte-macrophage derivation. Increases beyond a critical concentration of colony stimulating factor within the local milieu of the mononuclear phagocyte induces the coincident elaboration of prostaglandin E, a self-regulated response which serves to limit the unopposed humoral stimulation of myelopoiesis.",
author = "Kurland, {Jeffrey I.} and Bockman, {Richard S.} and Hal Broxmeyer and Moore, {Malcolm A S}",
year = "1978",
language = "English (US)",
volume = "199",
pages = "552--555",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "4328",

}

TY - JOUR

T1 - Limitation of excessive myelopoiesis by the intrinsic modulation of macrophage-derived prostaglandin E

AU - Kurland, Jeffrey I.

AU - Bockman, Richard S.

AU - Broxmeyer, Hal

AU - Moore, Malcolm A S

PY - 1978

Y1 - 1978

N2 - The clonal proliferation of the committed granulocyte-macrophage stem cell is controlled by a balance between mutually opposing factors, colony stimulating factor and prostaglandin E, both of monocyte-macrophage derivation. Increases beyond a critical concentration of colony stimulating factor within the local milieu of the mononuclear phagocyte induces the coincident elaboration of prostaglandin E, a self-regulated response which serves to limit the unopposed humoral stimulation of myelopoiesis.

AB - The clonal proliferation of the committed granulocyte-macrophage stem cell is controlled by a balance between mutually opposing factors, colony stimulating factor and prostaglandin E, both of monocyte-macrophage derivation. Increases beyond a critical concentration of colony stimulating factor within the local milieu of the mononuclear phagocyte induces the coincident elaboration of prostaglandin E, a self-regulated response which serves to limit the unopposed humoral stimulation of myelopoiesis.

UR - http://www.scopus.com/inward/record.url?scp=0018187636&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018187636&partnerID=8YFLogxK

M3 - Article

VL - 199

SP - 552

EP - 555

JO - Science

JF - Science

SN - 0036-8075

IS - 4328

ER -