Limitation of excessive myelopoiesis by the intrinsic modulation of macrophage-derived prostaglandin E

Jeffrey I. Kurland, Richard S. Bockman, Hal E. Broxmeyer, Malcolm A.S. Moore

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Abstract

The clonal proliferation of the committed granulocyte-macrophage stem cell is controlled by a balance between mutually opposing factors, colony stimulating factor and prostaglandin E, both of monocyte-macrophage derivation. Increases beyond a critical concentration of colony stimulating factor within the local milieu of the mononuclear phagocyte induces the coincident elaboration of prostaglandin E, a self-regulated response which serves to limit the unopposed humoral stimulation of myelopoiesis.

Original languageEnglish (US)
Pages (from-to)552-555
Number of pages4
JournalScience
Volume199
Issue number4328
DOIs
StatePublished - Jan 1 1978

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