Linkage mapping of Beta 2 EEG waves via non-parametric regression

Saurabh Ghosh, Henri Begleiter, Berniee Porjesz, David B. Chorlian, Howard Edenberg, Tatiana Foroud, Alison Goate, Theodore Reich

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Parametric linkage methods for analyzing quantitative trait loci are sensitive to violations in trait distributional assumptions. Non-parametric methods are relatively more robust. In this article, we modify the non-parametric regression procedure proposed by Ghosh and Majumder [2000: Am J Hum Genet 66:1046-1061] to map Beta 2 EEG waves using genome-wide data generated in the COGA project. Significant linkage findings are obtained on chromosomes 1, 4, 5, and 15 with findings at multiple regions on chromosomes 4 and 15. We analyze the data both with and without incorporating alcoholism as a covariate. We also test for epistatic interactions between regions of the genome exhibiting significant linkage with the EEG phenotypes and find evidence of epistatic interactions between a region each on chromosome 1 and chromosome 4 with one region on chromosome 15. While regressing out the effect of alcoholism does not affect the linkage findings, the epistatic interactions become statistically insignificant.

Original languageEnglish
Pages (from-to)66-71
Number of pages6
JournalAmerican Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Volume118 B
Issue number1
StatePublished - Apr 1 2003

Fingerprint

Chromosomes, Human, Pair 4
Chromosome Mapping
Chromosomes, Human, Pair 15
Electroencephalography
Chromosomes, Human, Pair 1
Alcoholism
Genome
Viverridae
Quantitative Trait Loci
Phenotype

Keywords

  • Alcoholism
  • Epistatic interaction
  • Quantitative trait

ASJC Scopus subject areas

  • Genetics(clinical)
  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)

Cite this

Linkage mapping of Beta 2 EEG waves via non-parametric regression. / Ghosh, Saurabh; Begleiter, Henri; Porjesz, Berniee; Chorlian, David B.; Edenberg, Howard; Foroud, Tatiana; Goate, Alison; Reich, Theodore.

In: American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, Vol. 118 B, No. 1, 01.04.2003, p. 66-71.

Research output: Contribution to journalArticle

Ghosh, S, Begleiter, H, Porjesz, B, Chorlian, DB, Edenberg, H, Foroud, T, Goate, A & Reich, T 2003, 'Linkage mapping of Beta 2 EEG waves via non-parametric regression', American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, vol. 118 B, no. 1, pp. 66-71.
Ghosh, Saurabh ; Begleiter, Henri ; Porjesz, Berniee ; Chorlian, David B. ; Edenberg, Howard ; Foroud, Tatiana ; Goate, Alison ; Reich, Theodore. / Linkage mapping of Beta 2 EEG waves via non-parametric regression. In: American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics. 2003 ; Vol. 118 B, No. 1. pp. 66-71.
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