Linkage of type II and type III cystinuria to 19q13.1

Codominant inheritance of two cystinuric alleles at 19q13.1 produces an extreme stone- forming phenotype

Marshall L. Stoller, Jeremy E. Bruce, Carol A. Bruce, Tatiana Foroud, Sandra C. Kirkwood, Peter J. Stambrook

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Cystinuria, a renal tubule disease affecting urinary cystine excretion with or without kidney stone formation, previously was mapped to chromosome region 2p.21. Mutations in the gene SLC3A1 or NBAT, the reported candidate gene for cystinuria at 2p.21, have been demonstrated in individuals with the autosomal recessive Type I cystinuria phenotype. Recently, the Type III cystinuria phenotype was mapped to chromosome region 19q13.1. Here we report a kindred of 39 persons in two families of cystinurics, Types II and III, that support linkage to 19q13.1 and exclude 2p.21. Based on a dominant model of inheritance, two-point analysis of the entire pedigree produced a maximum lod score (Z(max)) of 3.82 at marker D19S425. Multipoint analysis yielded a lod score of 4.96 at this marker, and a resultant lod score of 5.90 using a codominant model of inheritance. Furthermore, a candidate gene interval of 8.9 cM, flanked by markers D19S225 and D19S223, was obtained using multipoint and haplotype analyses. Thus, this kindred demonstrates the linkage of Type II cystinuria to 19q13.1 and confirms the linkage of Type III cystinuria at 19q13.1 while excluding the marker D19S225 that was previously included in the critical interval.

Original languageEnglish
Pages (from-to)134-139
Number of pages6
JournalAmerican Journal of Medical Genetics
Volume86
Issue number2
DOIs
StatePublished - Sep 10 1999

Fingerprint

Cystinuria
Alleles
Lod Score
Phenotype
Chromosomes
Genes
Kidney Calculi
Cystine
Phentolamine
Pedigree
Haplotypes
Kidney
Mutation

Keywords

  • Cystinuria
  • Human genetics
  • Kidney stone disease
  • Linkage
  • Metabolic disease

ASJC Scopus subject areas

  • Genetics(clinical)

Cite this

Linkage of type II and type III cystinuria to 19q13.1 : Codominant inheritance of two cystinuric alleles at 19q13.1 produces an extreme stone- forming phenotype. / Stoller, Marshall L.; Bruce, Jeremy E.; Bruce, Carol A.; Foroud, Tatiana; Kirkwood, Sandra C.; Stambrook, Peter J.

In: American Journal of Medical Genetics, Vol. 86, No. 2, 10.09.1999, p. 134-139.

Research output: Contribution to journalArticle

Stoller, Marshall L. ; Bruce, Jeremy E. ; Bruce, Carol A. ; Foroud, Tatiana ; Kirkwood, Sandra C. ; Stambrook, Peter J. / Linkage of type II and type III cystinuria to 19q13.1 : Codominant inheritance of two cystinuric alleles at 19q13.1 produces an extreme stone- forming phenotype. In: American Journal of Medical Genetics. 1999 ; Vol. 86, No. 2. pp. 134-139.
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