Linkage relationships of the Wiskott-Aldrich syndrome to 10 loci in the pericentromeric region of the human X chromosome

W. L. Greer, Ally-Khan Somani, P. C. Kwong, M. Peacocke, L. A. Rubin, K. A. Siminovitch

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Abstract

Twelve families with Wiskott-Aldrich syndrome (WAS) were studied by linkage analysis using 10 polymorphic marker loci from the X-chromosome pericentromeric region. The results confirm close linkage of WAS to the DXS14, DXS7, TIMP, and DXZ1 loci and are consistent with previous data suggesting that WAS maps to the proximal Xp and is flanked by the DXS14 and DXS7 loci. The strongest linkage (Z ̂ = 10.19 at θ = 0.00) was found to be between WAS and the hypervariable DXS255 locus, a marker locus already mapped between DXS7 and DXS14 and which was informative for all meioses included in this analysis. Linkage of the WAS to two pericentromeric Xq loci, DXS1 and PGK1, was also established. On the basis of these results, accurate predictive testing should now be feasible in the majority of WAS families.

Original languageEnglish (US)
Pages (from-to)568-571
Number of pages4
JournalGenomics
Volume6
Issue number3
DOIs
StatePublished - 1990
Externally publishedYes

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Chromosomes, Human, X
Wiskott-Aldrich Syndrome
Meiosis
X Chromosome

ASJC Scopus subject areas

  • Genetics

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Linkage relationships of the Wiskott-Aldrich syndrome to 10 loci in the pericentromeric region of the human X chromosome. / Greer, W. L.; Somani, Ally-Khan; Kwong, P. C.; Peacocke, M.; Rubin, L. A.; Siminovitch, K. A.

In: Genomics, Vol. 6, No. 3, 1990, p. 568-571.

Research output: Contribution to journalArticle

Greer, W. L. ; Somani, Ally-Khan ; Kwong, P. C. ; Peacocke, M. ; Rubin, L. A. ; Siminovitch, K. A. / Linkage relationships of the Wiskott-Aldrich syndrome to 10 loci in the pericentromeric region of the human X chromosome. In: Genomics. 1990 ; Vol. 6, No. 3. pp. 568-571.
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