Lipid binding domains

More than simple lipid effectors

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

The spatial and temporal regulation of lipid molecules in cell membranes is a hallmark of cellular signaling and membrane trafficking events. Lipid-mediated targeting provides for strict control and versatility, because cell membranes harbor a large number of lipid molecules with variation in head group and acyl chain structures. Signaling and trafficking proteins contain a large number of modular domains that exhibit specific lipid binding properties and play a critical role in their localization and function. Nearly 20 years of research including structural, computational, biochemical and biophysical studies have demonstrated how these lipid-binding domains recognize their target lipid and achieve subcellular localization. The integration of this individual lipid-binding domain data in the context of the full-length proteins, macromolecular signaling complexes, and the lipidome is only beginning to be unraveled and represents a target of therapeutic development. This review brings together recent findings and classical concepts to concisely summarize the lipid-binding domain field while illustrating where the field is headed and how the gaps may be filled in with new technologies.

Original languageEnglish
JournalJournal of Lipid Research
Volume50
Issue numberSUPPL.
DOIs
StatePublished - Apr 2009

Fingerprint

Lipids
Cell membranes
Cell Membrane
Cell signaling
Multiprotein Complexes
Molecules
Protein Transport
Ports and harbors
Proteins
Technology
Membranes
Research

Keywords

  • C1 domain
  • C2 domain
  • Peripheral protein

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Endocrinology

Cite this

Lipid binding domains : More than simple lipid effectors. / Stahelin, Robert.

In: Journal of Lipid Research, Vol. 50, No. SUPPL., 04.2009.

Research output: Contribution to journalArticle

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