Lipid binding domains: More than simple lipid effectors

Research output: Contribution to journalReview article

80 Scopus citations

Abstract

The spatial and temporal regulation of lipid molecules in cell membranes is a hallmark of cellular signaling and membrane trafficking events. Lipid-mediated targeting provides for strict control and versatility, because cell membranes harbor a large number of lipid molecules with variation in head group and acyl chain structures. Signaling and trafficking proteins contain a large number of modular domains that exhibit specific lipid binding properties and play a critical role in their localization and function. Nearly 20 years of research including structural, computational, biochemical and biophysical studies have demonstrated how these lipid-binding domains recognize their target lipid and achieve subcellular localization. The integration of this individual lipid-binding domain data in the context of the full-length proteins, macromolecular signaling complexes, and the lipidome is only beginning to be unraveled and represents a target of therapeutic development. This review brings together recent findings and classical concepts to concisely summarize the lipid-binding domain field while illustrating where the field is headed and how the gaps may be filled in with new technologies.

Original languageEnglish (US)
Pages (from-to)S299-S304
JournalJournal of Lipid Research
Volume50
Issue numberSUPPL.
DOIs
StatePublished - Apr 1 2009

Keywords

  • C1 domain
  • C2 domain
  • Peripheral protein

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Endocrinology

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