Lipid binding domains: More than simple lipid effectors

Research output: Contribution to journalReview article

79 Citations (Scopus)

Abstract

The spatial and temporal regulation of lipid molecules in cell membranes is a hallmark of cellular signaling and membrane trafficking events. Lipid-mediated targeting provides for strict control and versatility, because cell membranes harbor a large number of lipid molecules with variation in head group and acyl chain structures. Signaling and trafficking proteins contain a large number of modular domains that exhibit specific lipid binding properties and play a critical role in their localization and function. Nearly 20 years of research including structural, computational, biochemical and biophysical studies have demonstrated how these lipid-binding domains recognize their target lipid and achieve subcellular localization. The integration of this individual lipid-binding domain data in the context of the full-length proteins, macromolecular signaling complexes, and the lipidome is only beginning to be unraveled and represents a target of therapeutic development. This review brings together recent findings and classical concepts to concisely summarize the lipid-binding domain field while illustrating where the field is headed and how the gaps may be filled in with new technologies.

Original languageEnglish (US)
Pages (from-to)S299-S304
JournalJournal of Lipid Research
Volume50
Issue numberSUPPL.
DOIs
StatePublished - Apr 1 2009

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Lipids
Cell membranes
Cell Membrane
Cell signaling
Multiprotein Complexes
Molecules
Protein Transport
Ports and harbors
Proteins
Technology
Membranes
Research

Keywords

  • C1 domain
  • C2 domain
  • Peripheral protein

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Endocrinology

Cite this

Lipid binding domains : More than simple lipid effectors. / Stahelin, Robert V.

In: Journal of Lipid Research, Vol. 50, No. SUPPL., 01.04.2009, p. S299-S304.

Research output: Contribution to journalReview article

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