Lipid mediators of sensitivity in sensory neurons

Kellie A. Park, Michael Vasko

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Growing evidence implicates an increasing number of novel lipids, including eicosanoids, diacylglycerols, lysophosphatidic acids and ceramides, in augmenting the sensitivity of sensory neurons and enhancing pain perception. Many of these lipids are second messengers in signaling pathways that are associated with increasing the sensitivity of sensory neurons, whereas others are putative inflammatory mediators that activate either surface receptors or ion channels in these neurons. Based on the studies we review, it is clear that lipid-derived inflammatory mediators are a novel group of targets for therapeutics to treat inflammation and chronic pain states. However, much work remains to define the roles of these lipids in inflammation and the cellular mechanisms by which they alter the sensitivity of sensory neurons.

Original languageEnglish
Pages (from-to)571-577
Number of pages7
JournalTrends in Pharmacological Sciences
Volume26
Issue number11
DOIs
StatePublished - Nov 2005

Fingerprint

Sensory Receptor Cells
Neurons
Lipids
Lysophospholipids
Inflammation
Pain Perception
Eicosanoids
Ceramides
Diglycerides
Second Messenger Systems
Ion Channels
Chronic Pain
Therapeutics

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

Cite this

Lipid mediators of sensitivity in sensory neurons. / Park, Kellie A.; Vasko, Michael.

In: Trends in Pharmacological Sciences, Vol. 26, No. 11, 11.2005, p. 571-577.

Research output: Contribution to journalArticle

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