Lipophilicity coefficients of [11C]Me-Halo-CGS 27023A analogs determined by HPLC

Xiangshu Fei, Qi-Huang Zheng

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

New radiolabeled matrix metalloproteinase inhibitors (MMPIs) [ 11C]Me-Halo-CGS 27023A analogs have been synthesized for evaluation as potential novel positron emission tomography (PET) tumor imaging agents. Their lipophilicity coefficients (log P) were determined by C-18 reversed-phase HPLC method. These logP values were compared, and the correlations between lipophilicity and biological activity of selected analogs were made. The results suggest the appropriate level of lipophilic character in this class of compounds as useful imaging agents appears to be in the range of 2.00-2.67.

Original languageEnglish
Pages (from-to)939-945
Number of pages7
JournalJournal of Liquid Chromatography and Related Technologies
Volume28
Issue number6
DOIs
StatePublished - 2005

Fingerprint

Matrix Metalloproteinase Inhibitors
Positron-Emission Tomography
High Pressure Liquid Chromatography
Imaging techniques
Positron emission tomography
Bioactivity
Tumors
Neoplasms
CGS 27023A

Keywords

  • [C]Me-Halo-CGS 27023A
  • HPLC
  • Lipophilicity coefficients
  • Positron emission tomography
  • Tumor imaging agents

ASJC Scopus subject areas

  • Analytical Chemistry
  • Clinical Biochemistry

Cite this

Lipophilicity coefficients of [11C]Me-Halo-CGS 27023A analogs determined by HPLC. / Fei, Xiangshu; Zheng, Qi-Huang.

In: Journal of Liquid Chromatography and Related Technologies, Vol. 28, No. 6, 2005, p. 939-945.

Research output: Contribution to journalArticle

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