Lipophilicity coefficients of [11C]Me-Halo-CGS 27023A analogs determined by HPLC

Xiangshu Fei, Qi Huang Zheng

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

New radiolabeled matrix metalloproteinase inhibitors (MMPIs) [ 11C]Me-Halo-CGS 27023A analogs have been synthesized for evaluation as potential novel positron emission tomography (PET) tumor imaging agents. Their lipophilicity coefficients (log P) were determined by C-18 reversed-phase HPLC method. These logP values were compared, and the correlations between lipophilicity and biological activity of selected analogs were made. The results suggest the appropriate level of lipophilic character in this class of compounds as useful imaging agents appears to be in the range of 2.00-2.67.

Original languageEnglish (US)
Pages (from-to)939-945
Number of pages7
JournalJournal of Liquid Chromatography and Related Technologies
Volume28
Issue number6
DOIs
StatePublished - Apr 14 2005

Keywords

  • [C]Me-Halo-CGS 27023A
  • HPLC
  • Lipophilicity coefficients
  • Positron emission tomography
  • Tumor imaging agents

ASJC Scopus subject areas

  • Analytical Chemistry
  • Clinical Biochemistry

Fingerprint Dive into the research topics of 'Lipophilicity coefficients of [<sup>11</sup>C]Me-Halo-CGS 27023A analogs determined by HPLC'. Together they form a unique fingerprint.

  • Cite this