Lipopolysaccharide and peptidoglycan: CD14-dependent bacterial inducers of inflammation

Ernst Th Rietschel, Jens Schletter, Birgit Weidemann, Volker El-Samalouti, Taila Mattern, Ulrich Zähringer, Ulrich Seydel, Helmut Brade, Hans Dieter Flad, Shoichi Kusumoto, Dipika Gupta, Roman Dziarski, Artur J. Ulmer

Research output: Contribution to journalReview article

75 Scopus citations

Abstract

Surface structures of bacteria contribute to the microbial pathogenic potential and are capable of causing local and generalized inflammatory reactions. Among these factors, endotoxin and peptidoglycan are of particular medical importance. Both toxic bacterial polymers are now recognized to interact with the same cellular receptor, the CD14 molecule, which is expressed on different types of immune cells, in particular, monocytes/macrophages. The interaction between these bacterial activators and CD14 leads to the production of endogenous mediators such as tumor necrosis factor α, interleukin 1 (IL-1), and IL-6, which are ultimately responsible for phlogistic responses. The fact that CD14 recognizes not only endotoxin and peptidoglycan but also other glycosyl-based microbial polymers suggests that this cellular surface molecule represents a lectin.

Original languageEnglish (US)
Pages (from-to)37-44
Number of pages8
JournalMicrobial Drug Resistance
Volume4
Issue number1
DOIs
StatePublished - Jan 1 1998

    Fingerprint

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Pharmacology
  • Microbiology (medical)

Cite this

Rietschel, E. T., Schletter, J., Weidemann, B., El-Samalouti, V., Mattern, T., Zähringer, U., Seydel, U., Brade, H., Flad, H. D., Kusumoto, S., Gupta, D., Dziarski, R., & Ulmer, A. J. (1998). Lipopolysaccharide and peptidoglycan: CD14-dependent bacterial inducers of inflammation. Microbial Drug Resistance, 4(1), 37-44. https://doi.org/10.1089/mdr.1998.4.37