Lipoprotein-associated phospholipase A2 and risk of congestive heart failure in older adults the cardiovascular health study

Takeki Suzuki, Cam Solomon, Nancy Swords Jenny, Russell Tracy, Jeanenne J. Nelson, Bruce M. Psaty, Curt Furberg, Mary Cushman

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Background-Inflammation may be a causative factor in congestive heart failure (CHF). Lipoprotein-associated phospholipase A2 (Lp-PLA 2) is an inflammation marker associated with vascular risk. One previous study showed an association of Lp-PLA2 activity with CHF risk, but there were only 94 CHF cases and Lp-PLA2 antigen, which is available clinically in the United States, was not measured. Methods and Results-We measured baseline Lp-PLA2 antigen and activity in 3991 men and women without baseline CHF or cardiovascular disease who were participating in the Cardiovascular Health Study, a prospective observational study of adults 65 years or older. Cox proportional hazards models adjusted for age, sex, clinic site, race, low-density and high-density lipoprotein cholesterol, body mass index, systolic and diastolic blood pressure, hypertension, smoking status, pack-years, and diabetes were used to calculate hazard ratios and 95% CIs for incident CHF. Further models adjusted for coronary disease events during follow-up and C-reactive protein. Eight hundred twenty-nine participants developed CHF during 12.1 years. Adjusted hazard ratios for CHF with Lp-PLA 2 in the fourth compared with the first quartile were 1.44 (95% CI, 1.16 to 1.79) for Lp-PLA2 antigen and 1.06 (95% CI, 0.84 to 1.32) for activity. Adjustment for incident coronary disease attenuated the hazard ratio for Lp-PLA2 antigen to 1.26 (95% CI, 1.02 to 1.57), adjustment for C-reactive protein had minimal impact. Conclusions-Lp-PLA2 antigen was associated with risk of future CHF in older people, independent of CHF and coronary risk factors, and partly mediated by coronary disease events. Further clinical and basic research is needed to better understand the role of Lp-PLA2 in CHF.

Original languageEnglish (US)
Pages (from-to)429-436
Number of pages8
JournalCirculation: Heart Failure
Volume2
Issue number5
DOIs
StatePublished - Sep 1 2009
Externally publishedYes

Keywords

  • Epidemiology
  • Heart failure

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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