Liposomal Bupivacaine Versus Traditional Periarticular Injection for Pain Control After Total Knee Arthroplasty

Deren T. Bagsby, Phillip H. Ireland, R. Michael Meneghini

Research output: Contribution to journalArticle

101 Scopus citations

Abstract

The purpose of this study was to compare a novel liposomal bupivacaine to traditional peri-articular injection (PAI) in a multi-modal pain protocol for total knee arthroplasty (TKA). A retrospective cohort study compared 85 consecutive patients undergoing TKA with a traditional PAI of ropivacaine, epinephrine and morphine to 65 patients with a liposomal bupivacaine PAI. After the initial 24. h, inpatient self-reported pain scores were higher in the liposomal bupivacaine group compared to the traditional PAI group (P = 0.04) and a smaller percentage (16.9%) of patients in the liposomal bupivacaine group rated their pain as "mild" compared to the traditional group (47.6%). Liposomal bupivacaine PAI provided inferior pain control compared to the less expensive traditional PAI in a multi-modal pain control program in patients undergoing TKA.

Original languageEnglish (US)
Pages (from-to)1687-1690
Number of pages4
JournalJournal of Arthroplasty
Volume29
Issue number8
DOIs
StatePublished - Aug 2014

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Keywords

  • Bupivacaine
  • Knee arthroplasty
  • Liposomal
  • Pain control
  • Periarticular injection

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine

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