Liposome-encapsulated3H-5FU in rabbits

Peggy Fishman, Gholam A. Peyman, Robert Hendricks, Siu Lui Hui

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

We compared the pharmacokinetics of liposome-encapsulated tritiated 5-fluorouracil (3H-5FU-Lipo) to3H-5FU in buffered saline (3H-5FU-PBS) after subconjunctival or intravitreal injection into rabbit eyes. Liposomes were prepared using phosphatidylcholine, phosphatidic acid, and alpha-tocopherol. Following a unilateral subconjunctival injection of either3H-5FU-Lipo or3H-5FU-PBS, rabbits were sacrificed at 0.5, 1, 4, and 8 hours. Significantly higher (p<0.05) drug levels were achieved with the encapsulated drug in the vitreous at all four time points and in the aqueous at three of four time points. Following bilateral intravitreal injections of 500 μg of 5FU in 0.1 ml, as either3H-5FU-Lipo or3H-5FU-PBS injected rabbits were sacrificed at 0, 6, 12, 24, and 48 hours. Vitreal drug levels were significantly higher (p<0.05) with encapsulated drug at all time points from 6 hours on. At 48 hours, the vitreal level with the encapsulated drug was 578±0.23 μg/ml compared with 1.06±0.07 μg/ml for3H-5FU-PBS.

Original languageEnglish (US)
Pages (from-to)361-365
Number of pages5
JournalInternational Ophthalmology
Volume13
Issue number5
DOIs
StatePublished - Sep 1 1989
Externally publishedYes

Keywords

  • 5-fluorouracil
  • intravitreal
  • liposome
  • subconjunctival

ASJC Scopus subject areas

  • Ophthalmology

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