Literature-based discovery of salivary biomarkers for type 2 diabetes mellitus

Mythily Srinivasan, Corinne Blackburn, Mohamed Mohamed, A. V. Sivagami, Janice Blum

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The alarming increase in type 2 diabetes mellitus (T2DM) underscores the need for efficient screening and preventive strategies. Select protein biomarker profiles emerge over time during T2DM development. Periodic evaluation of these markers will increase the predictive ability of diabetes risk scores. Noninvasive methods for frequent measurements of biomarkers are increasingly being investigated. Application of salivary diagnostics has gained importance with the establishment of significant similarities between the salivary and serum proteomes. The objective of this study is to identify T2DM-specific salivary biomarkers by literature-based discovery. A serial interrogation of the PubMed database was performed using MeSH terms of specific T2DM pathological processes in primary and secondary iterations to compile cohorts of T2DM-specific serum markers. Subsequent search consisted of mining for the identified serum markers in human saliva. More than 60% of T2DM-associated serum proteins have been measured in saliva. Nearly half of these proteins have been reported in diabetic saliva. Measurements of salivary lipids and oxidative stress markers that can exhibit correlated saliva plasma ratio could constitute reliable factors for T2DM risk assessment. We conclude that a high percentage of T2DM-associated serum proteins can be measured in saliva, which offers an attractive and economical strategy for T2DM screening.

Original languageEnglish (US)
Pages (from-to)39-45
Number of pages7
JournalBiomarker Insights
Volume10
DOIs
StatePublished - May 14 2015

Fingerprint

Literature Based Discovery
Biomarkers
Medical problems
Type 2 Diabetes Mellitus
Saliva
Blood Proteins
Screening
Oxidative stress
Pathologic Processes
Proteome
PubMed

Keywords

  • Circulating biomarkers
  • Diabetes mellitus
  • Literature-based search
  • Salivary proteins

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Biochemistry, medical

Cite this

Literature-based discovery of salivary biomarkers for type 2 diabetes mellitus. / Srinivasan, Mythily; Blackburn, Corinne; Mohamed, Mohamed; Sivagami, A. V.; Blum, Janice.

In: Biomarker Insights, Vol. 10, 14.05.2015, p. 39-45.

Research output: Contribution to journalArticle

Srinivasan, Mythily ; Blackburn, Corinne ; Mohamed, Mohamed ; Sivagami, A. V. ; Blum, Janice. / Literature-based discovery of salivary biomarkers for type 2 diabetes mellitus. In: Biomarker Insights. 2015 ; Vol. 10. pp. 39-45.
@article{d759a6be079c434b907bce78a50ef359,
title = "Literature-based discovery of salivary biomarkers for type 2 diabetes mellitus",
abstract = "The alarming increase in type 2 diabetes mellitus (T2DM) underscores the need for efficient screening and preventive strategies. Select protein biomarker profiles emerge over time during T2DM development. Periodic evaluation of these markers will increase the predictive ability of diabetes risk scores. Noninvasive methods for frequent measurements of biomarkers are increasingly being investigated. Application of salivary diagnostics has gained importance with the establishment of significant similarities between the salivary and serum proteomes. The objective of this study is to identify T2DM-specific salivary biomarkers by literature-based discovery. A serial interrogation of the PubMed database was performed using MeSH terms of specific T2DM pathological processes in primary and secondary iterations to compile cohorts of T2DM-specific serum markers. Subsequent search consisted of mining for the identified serum markers in human saliva. More than 60{\%} of T2DM-associated serum proteins have been measured in saliva. Nearly half of these proteins have been reported in diabetic saliva. Measurements of salivary lipids and oxidative stress markers that can exhibit correlated saliva plasma ratio could constitute reliable factors for T2DM risk assessment. We conclude that a high percentage of T2DM-associated serum proteins can be measured in saliva, which offers an attractive and economical strategy for T2DM screening.",
keywords = "Circulating biomarkers, Diabetes mellitus, Literature-based search, Salivary proteins",
author = "Mythily Srinivasan and Corinne Blackburn and Mohamed Mohamed and Sivagami, {A. V.} and Janice Blum",
year = "2015",
month = "5",
day = "14",
doi = "10.4137/BMI.S22177",
language = "English (US)",
volume = "10",
pages = "39--45",
journal = "Biomarker Insights",
issn = "1177-2719",
publisher = "Libertas Academica Ltd.",

}

TY - JOUR

T1 - Literature-based discovery of salivary biomarkers for type 2 diabetes mellitus

AU - Srinivasan, Mythily

AU - Blackburn, Corinne

AU - Mohamed, Mohamed

AU - Sivagami, A. V.

AU - Blum, Janice

PY - 2015/5/14

Y1 - 2015/5/14

N2 - The alarming increase in type 2 diabetes mellitus (T2DM) underscores the need for efficient screening and preventive strategies. Select protein biomarker profiles emerge over time during T2DM development. Periodic evaluation of these markers will increase the predictive ability of diabetes risk scores. Noninvasive methods for frequent measurements of biomarkers are increasingly being investigated. Application of salivary diagnostics has gained importance with the establishment of significant similarities between the salivary and serum proteomes. The objective of this study is to identify T2DM-specific salivary biomarkers by literature-based discovery. A serial interrogation of the PubMed database was performed using MeSH terms of specific T2DM pathological processes in primary and secondary iterations to compile cohorts of T2DM-specific serum markers. Subsequent search consisted of mining for the identified serum markers in human saliva. More than 60% of T2DM-associated serum proteins have been measured in saliva. Nearly half of these proteins have been reported in diabetic saliva. Measurements of salivary lipids and oxidative stress markers that can exhibit correlated saliva plasma ratio could constitute reliable factors for T2DM risk assessment. We conclude that a high percentage of T2DM-associated serum proteins can be measured in saliva, which offers an attractive and economical strategy for T2DM screening.

AB - The alarming increase in type 2 diabetes mellitus (T2DM) underscores the need for efficient screening and preventive strategies. Select protein biomarker profiles emerge over time during T2DM development. Periodic evaluation of these markers will increase the predictive ability of diabetes risk scores. Noninvasive methods for frequent measurements of biomarkers are increasingly being investigated. Application of salivary diagnostics has gained importance with the establishment of significant similarities between the salivary and serum proteomes. The objective of this study is to identify T2DM-specific salivary biomarkers by literature-based discovery. A serial interrogation of the PubMed database was performed using MeSH terms of specific T2DM pathological processes in primary and secondary iterations to compile cohorts of T2DM-specific serum markers. Subsequent search consisted of mining for the identified serum markers in human saliva. More than 60% of T2DM-associated serum proteins have been measured in saliva. Nearly half of these proteins have been reported in diabetic saliva. Measurements of salivary lipids and oxidative stress markers that can exhibit correlated saliva plasma ratio could constitute reliable factors for T2DM risk assessment. We conclude that a high percentage of T2DM-associated serum proteins can be measured in saliva, which offers an attractive and economical strategy for T2DM screening.

KW - Circulating biomarkers

KW - Diabetes mellitus

KW - Literature-based search

KW - Salivary proteins

UR - http://www.scopus.com/inward/record.url?scp=84981712835&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84981712835&partnerID=8YFLogxK

U2 - 10.4137/BMI.S22177

DO - 10.4137/BMI.S22177

M3 - Article

AN - SCOPUS:84981712835

VL - 10

SP - 39

EP - 45

JO - Biomarker Insights

JF - Biomarker Insights

SN - 1177-2719

ER -