Literature Review and Meta-Analysis of Topical Carbonic Anhydrase Inhibitors and Ocular Blood Flow

Brent Siesky, Alon Harris, Edward Brizendine, Clarice Marques, Jennifer Loh, Joseph Mackey, Jennifer Overton, Peter Netland

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

The purpose of this literature review and meta-analysis was to determine what, if any, effects topical carbonic anhydrase inhibitors have on ocular hemodynamics in humans. A literature review and meta-analysis was conducted to investigate the effects of topical carbonic anhydrase inhibitors on ocular blood flow. Thirty-five articles were evaluated according to the inclusion criteria with 13 manuscripts meeting requirements for statistical analysis. Each study's effect size, defined as the change in blood flow measures after treatment with topical carbonic anhydrase inhibitors, was estimated using the weighted mean difference. Based on this meta-analysis, we conclude that topical carbonic anhydrase inhibitors increase ocular blood flow velocities in the retinal circulation, central retinal and short posterior ciliary arteries, but not in the ophthalmic artery.

Original languageEnglish
Pages (from-to)33-46
Number of pages14
JournalSurvey of Ophthalmology
Volume54
Issue number1
DOIs
StatePublished - Jan 2009

Fingerprint

Carbonic Anhydrase Inhibitors
Meta-Analysis
Ciliary Arteries
Ophthalmic Artery
Blood Flow Velocity
Manuscripts
Hemodynamics

Keywords

  • carbonic anhydrase inhibitor
  • color Doppler imaging
  • glaucoma
  • ocular blood flow
  • scanning laser ophthalmoscopy

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Literature Review and Meta-Analysis of Topical Carbonic Anhydrase Inhibitors and Ocular Blood Flow. / Siesky, Brent; Harris, Alon; Brizendine, Edward; Marques, Clarice; Loh, Jennifer; Mackey, Joseph; Overton, Jennifer; Netland, Peter.

In: Survey of Ophthalmology, Vol. 54, No. 1, 01.2009, p. 33-46.

Research output: Contribution to journalArticle

Siesky, Brent ; Harris, Alon ; Brizendine, Edward ; Marques, Clarice ; Loh, Jennifer ; Mackey, Joseph ; Overton, Jennifer ; Netland, Peter. / Literature Review and Meta-Analysis of Topical Carbonic Anhydrase Inhibitors and Ocular Blood Flow. In: Survey of Ophthalmology. 2009 ; Vol. 54, No. 1. pp. 33-46.
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