Literature review and meta-analysis of translaminar pressure difference in open-angle glaucoma

L. Siaudvytyte, I. Januleviciene, A. Daveckaite, A. Ragauskas, L. Bartusis, J. Kucinoviene, Brent Siesky, Alon Harris

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

There is increasing evidence in the literature regarding translaminar pressure difference's (TPD) role in the pathophysiology of glaucoma. The optic nerve is exposed not only to intraocular pressure in the eye, but also to intracranial pressure (ICP), as it is surrounded by cerebrospinal fluid in the subarachnoid space. Although pilot studies have identified the potential importance of TPD in glaucoma, limited available data currently prevent a comprehensive description of the role that TPD may have in glaucomatous pathophysiology. In this review, we present all available qualified data from a systematic review of the literature of the role of TPD in open-angle glaucoma (OAG). PubMed (Medline), OVID Medline, ScienceDirect, SpringerLink, and all available library databases were reviewed and subsequent meta-analysis of pooled mean differences are presented where appropriate. Five papers including 396 patients met criteria for inclusion to the analysis. Importantly, we included all observational studies despite differences in ICP measurement methods, as there is no consensus regarding best-practice ICP measurements in glaucoma. Our results show that not only TPD is higher in glaucoma patients compared with healthy subjects, it is related to structural glaucomatous changes of the optic disc. Our analysis suggests further longitudinal prospective studies are needed to investigate the influence of TPD in OAG, with a goal of overcoming methodological weaknesses of previous studies.

Original languageEnglish (US)
Pages (from-to)1242-1250
Number of pages9
JournalEye (Basingstoke)
Volume29
Issue number10
DOIs
StatePublished - Oct 1 2015

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Open Angle Glaucoma
Meta-Analysis
Pressure
Glaucoma
Intracranial Pressure
Subarachnoid Space
Optic Disk
Optic Nerve
Intraocular Pressure
Practice Guidelines
PubMed
Libraries
Observational Studies
Longitudinal Studies
Cerebrospinal Fluid
Healthy Volunteers
Databases
Prospective Studies

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Siaudvytyte, L., Januleviciene, I., Daveckaite, A., Ragauskas, A., Bartusis, L., Kucinoviene, J., ... Harris, A. (2015). Literature review and meta-analysis of translaminar pressure difference in open-angle glaucoma. Eye (Basingstoke), 29(10), 1242-1250. https://doi.org/10.1038/eye.2015.127

Literature review and meta-analysis of translaminar pressure difference in open-angle glaucoma. / Siaudvytyte, L.; Januleviciene, I.; Daveckaite, A.; Ragauskas, A.; Bartusis, L.; Kucinoviene, J.; Siesky, Brent; Harris, Alon.

In: Eye (Basingstoke), Vol. 29, No. 10, 01.10.2015, p. 1242-1250.

Research output: Contribution to journalArticle

Siaudvytyte, L, Januleviciene, I, Daveckaite, A, Ragauskas, A, Bartusis, L, Kucinoviene, J, Siesky, B & Harris, A 2015, 'Literature review and meta-analysis of translaminar pressure difference in open-angle glaucoma', Eye (Basingstoke), vol. 29, no. 10, pp. 1242-1250. https://doi.org/10.1038/eye.2015.127
Siaudvytyte L, Januleviciene I, Daveckaite A, Ragauskas A, Bartusis L, Kucinoviene J et al. Literature review and meta-analysis of translaminar pressure difference in open-angle glaucoma. Eye (Basingstoke). 2015 Oct 1;29(10):1242-1250. https://doi.org/10.1038/eye.2015.127
Siaudvytyte, L. ; Januleviciene, I. ; Daveckaite, A. ; Ragauskas, A. ; Bartusis, L. ; Kucinoviene, J. ; Siesky, Brent ; Harris, Alon. / Literature review and meta-analysis of translaminar pressure difference in open-angle glaucoma. In: Eye (Basingstoke). 2015 ; Vol. 29, No. 10. pp. 1242-1250.
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