Lithium: A novel treatment for Alzheimer's disease?

Jin Zhong, Wei Hua Lee

Research output: Contribution to journalReview article

35 Scopus citations


Lithium is an alkali metal. First described as a mood stabilizer in 1949, it remains an efficacious treatment for bipolar disorders. Recent emerging evidence of its neuroprotective and neurogenic effects alludes to lithium's potential therapeutic use in stroke and neurodegenerative diseases. One intriguing clinical application is in the treatment of Alzheimer's disease. Ongoing clinical trials are evaluating lithium's abilities to lower τ and β-amyloid levels in cerebrospinal fluid in Alzheimer's patients. This review summarizes the supporting evidence and safety profiles of lithium's use in the treatment of neurological diseases, especially Alzheimer's disease.

Original languageEnglish (US)
Pages (from-to)375-383
Number of pages9
JournalExpert Opinion on Drug Safety
Issue number4
StatePublished - Jul 1 2007


  • Alzheimer's disease
  • Glycogen synthase kinase
  • Lithium
  • Safety

ASJC Scopus subject areas

  • Pharmacology

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