Lithium ratio in psychiatric patients: A caveat

John I. Nurnberger, Ghanshyam Pandey, Elliot S. Gershon, John M. Davis

Research output: Contribution to journalArticle

8 Scopus citations


We divided bipolar patients samples into two groups: Group I (off lithium 10 days to 2 weeks, n=14)and group II (off lithium 3 weeks or longer, n=13). Only group I was significantly different from controls. The mean for group II was significantly different from that for group I but not that for controls. Previous reports may have exaggerated the number of "high ratio" patients due to a treatment artifact. We recommend that patients be tested only after having been withdrawn from lithium treatment for 3 weeks or more. Otherwise spurious differences between patients and controls may result.

Original languageEnglish (US)
Pages (from-to)201-206
Number of pages6
JournalPsychiatry Research
Issue number3
StatePublished - Jul 1983
Externally publishedYes



  • Lithium ratio
  • bipolar illness
  • treatment artifact

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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