Liver retransplantation of patients with hepatitis C infection is associated with acceptable patient and graft survival

Marwan Ghabril, Rolland C. Dickson, Victor I. Machicao, Jaime Aranda-Michel, Andrew Keaveny, Barry Rosser, Hugo Bonatti, Murli Krishna, Maria Yataco, Raj Satyanarayana, Denise Harnois, Winston Hewitt, Darin D. Willingham, Hani Grewal, Christopher B. Hughes, Justin Nguyen

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Infection with hepatitis C virus (HCV) is the leading cause of liver transplantation (LT), while liver retransplantation (RT) for HCV is controversial as a result of concerns over poor outcomes. We sought to compare patient and graft survival after RT in patients with and without HCV. We performed a retrospective chart review of all patients undergoing RT at our center between February 1998 and April 2004. Indications for RT, HCV status, patient, and donor characteristics, laboratory values, and hospitalization status at RT were collected. A total of 108 patients (48 HCV and 60 non-HCV) underwent RT during the study period, with mean post-RT follow-up of 1,096 days (range, 0-2,888 days). Grafts from donors aged>60 years were used less frequently in HCV patients at RT (6%) compared with LT (47%), P < 0.001. There was no difference between HCV vs. non-HCV patients in 1- and 3-year patient survival (respectively, 79% vs. 63%, and 71% vs. 63%) and graft survival (respectively, 67% vs. 66%, and 59% vs. 56%). Post-RT mortality and graft failure in HCV patients occurred within the first year in 89% of patients, and 83% were unrelated to HCV recurrence. We conclude that patients should not be excluded from consideration for retransplantation solely on the basis of a diagnosis of HCV.

Original languageEnglish (US)
Pages (from-to)1717-1727
Number of pages11
JournalLiver Transplantation
Volume13
Issue number12
DOIs
StatePublished - Dec 1 2007
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Hepatology
  • Transplantation

Fingerprint Dive into the research topics of 'Liver retransplantation of patients with hepatitis C infection is associated with acceptable patient and graft survival'. Together they form a unique fingerprint.

  • Cite this

    Ghabril, M., Dickson, R. C., Machicao, V. I., Aranda-Michel, J., Keaveny, A., Rosser, B., Bonatti, H., Krishna, M., Yataco, M., Satyanarayana, R., Harnois, D., Hewitt, W., Willingham, D. D., Grewal, H., Hughes, C. B., & Nguyen, J. (2007). Liver retransplantation of patients with hepatitis C infection is associated with acceptable patient and graft survival. Liver Transplantation, 13(12), 1717-1727. https://doi.org/10.1002/lt.21292