Liver transplantation after radioembolization in a patient with unresectable HCC

Laura E Moreno Luna, Paul Y. Kwo, Lewis R. Roberts, Teresa A. Mettler, Denise N. Gansen, James C. Andrews, Gregory A. Wiseman, Vijay Laxmi Misra

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background. A 58-year-old white man who was being followed by his hepatologist for nonalcoholic steatohepatitis-related liver cirrhosis and portal hypertension and who had been found to have a biopsy-proven hepatocellular carcinoma (HCC) on routine screening, self-referred to our center for a second opinion on the management of his HCC. Investigations. Laboratory investigations, CT scan of the abdomen and chest, bone scan and technetium macroaggregated albumin scan. Diagnosis. The patient had unresectable HCC. Management. The patient underwent two treatments with Yttrium-90 glass microspheres, which were performed as outpatient procedures 1 month and 3 months after diagnosis. He underwent orthotopic liver transplantation (OLT) 1 year after the initial diagnosis of HCC. The post-OLT immunoregimen included OKT3 plus rituximab and high-dose steroids. On discharge from hospital he was on immunosuppressive treatment with tacrolimus. He had de novo autoimmune hepatitis 6 months post-OLT, which was treated with a short course of low-dose steroids and addition of mycophenolate mofetil.

Original languageEnglish
Pages (from-to)679-683
Number of pages5
JournalNature Reviews Gastroenterology and Hepatology
Volume6
Issue number11
DOIs
StatePublished - 2009

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Liver Transplantation
Hepatocellular Carcinoma
Steroids
Mycophenolic Acid
Yttrium
Muromonab-CD3
Autoimmune Hepatitis
Technetium
Portal Hypertension
Tacrolimus
Immunosuppressive Agents
Microspheres
Liver Cirrhosis
Abdomen
Glass
Albumins
Outpatients
Thorax
Referral and Consultation
Biopsy

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

Cite this

Luna, L. E. M., Kwo, P. Y., Roberts, L. R., Mettler, T. A., Gansen, D. N., Andrews, J. C., ... Misra, V. L. (2009). Liver transplantation after radioembolization in a patient with unresectable HCC. Nature Reviews Gastroenterology and Hepatology, 6(11), 679-683. https://doi.org/10.1038/nrgastro.2009.165

Liver transplantation after radioembolization in a patient with unresectable HCC. / Luna, Laura E Moreno; Kwo, Paul Y.; Roberts, Lewis R.; Mettler, Teresa A.; Gansen, Denise N.; Andrews, James C.; Wiseman, Gregory A.; Misra, Vijay Laxmi.

In: Nature Reviews Gastroenterology and Hepatology, Vol. 6, No. 11, 2009, p. 679-683.

Research output: Contribution to journalArticle

Luna, LEM, Kwo, PY, Roberts, LR, Mettler, TA, Gansen, DN, Andrews, JC, Wiseman, GA & Misra, VL 2009, 'Liver transplantation after radioembolization in a patient with unresectable HCC', Nature Reviews Gastroenterology and Hepatology, vol. 6, no. 11, pp. 679-683. https://doi.org/10.1038/nrgastro.2009.165
Luna, Laura E Moreno ; Kwo, Paul Y. ; Roberts, Lewis R. ; Mettler, Teresa A. ; Gansen, Denise N. ; Andrews, James C. ; Wiseman, Gregory A. ; Misra, Vijay Laxmi. / Liver transplantation after radioembolization in a patient with unresectable HCC. In: Nature Reviews Gastroenterology and Hepatology. 2009 ; Vol. 6, No. 11. pp. 679-683.
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