Local action of oral 1,25-dihydroxycholecalciferol on calcium absorption in osteoporosis

R. M. Francis, M. Peacock

Research output: Contribution to journalArticle

26 Scopus citations


To investigate whether low calcium absorption in osteoporosis improves by increasing 1,25-dihydroxyvitamin D both systematically in plasma and locally in gut, the effects of oral 25-hydroxycholecalciferol and oral 1,25-dihydroxycholecalciferol on plasma 1,25-dihydroxy-vitamin D (1,25-(OH)2D) and calcium absorption were studied in 20 postmenopausal patients with vertebral osteoporosis. In 10 patients taking oral 0.25 μg 1,25-dihydroxycholecalciferol twice daily for 7 d, calcium absorption increased more than in 10 patients taking oral 40 μg 25-hydroxycholecalciferol once daily for 7 d (p < 0.02) despite both groups having a similar increase in plasma 1,25-(OH)2D. These results support the view that the major effects of oral 1,25-dihydroxycholecalciferol on absorption is due to a local action on the gut and that it is possible to increase calcium absorption in osteoporosis with oral 1,25-dihydroxycholecalciferol without increasing its undesirable action on bone resorption.

Original languageEnglish (US)
Pages (from-to)315-318
Number of pages4
JournalAmerican Journal of Clinical Nutrition
Issue number2
StatePublished - Jan 1 1987

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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