Local communication on and within bone controls bone remodeling

Kim Henriksen, Anita V. Neutzsky-Wulff, Lynda Bonewald, Morten A. Karsdal

Research output: Contribution to journalReview article

159 Citations (Scopus)

Abstract

Bone remodeling is required for healthy calcium homeostasis and for repair of damage occurring with stress and age. Osteoclasts resorb bone and osteoblasts form bone. These processes normally occur in a tightly regulated sequence of events, where the amount of formed bone equals the amount of resorbed bone, thereby restoring the removed bone completely. Osteocytes are the third cell type playing an essential role in bone turnover. They appear to regulate activation of bone remodeling, and they exert both positive and negative regulation on both osteoclasts and osteoblasts. In this review, we consider the intricate communication between these bone cells in relation to bone remodeling, reviewing novel data from patients with mutations rendering different cell populations inactive, which have shown that these interactions are more complex than originally thought. We highlight the high probability that a detailed understanding of these processes will aid in the development of novel treatments for bone metabolic disorders, i.e. we discuss the possibility that bone resorption can be attenuated pharmacologically without a secondary reduction in bone formation.

Original languageEnglish (US)
Pages (from-to)1026-1033
Number of pages8
JournalBone
Volume44
Issue number6
DOIs
StatePublished - Jun 2009
Externally publishedYes

Fingerprint

Bone Remodeling
Communication
Bone and Bones
Osteoclasts
Osteoblasts
Osteocytes
Bone Resorption
Osteogenesis
Homeostasis
Calcium
Mutation
Population

Keywords

  • Coupling
  • Osteoblasts
  • Osteoclasts
  • Osteocytes
  • Osteopetrosis
  • Remodeling

ASJC Scopus subject areas

  • Physiology
  • Endocrinology, Diabetes and Metabolism
  • Histology

Cite this

Henriksen, K., Neutzsky-Wulff, A. V., Bonewald, L., & Karsdal, M. A. (2009). Local communication on and within bone controls bone remodeling. Bone, 44(6), 1026-1033. https://doi.org/10.1016/j.bone.2009.03.671

Local communication on and within bone controls bone remodeling. / Henriksen, Kim; Neutzsky-Wulff, Anita V.; Bonewald, Lynda; Karsdal, Morten A.

In: Bone, Vol. 44, No. 6, 06.2009, p. 1026-1033.

Research output: Contribution to journalReview article

Henriksen, K, Neutzsky-Wulff, AV, Bonewald, L & Karsdal, MA 2009, 'Local communication on and within bone controls bone remodeling', Bone, vol. 44, no. 6, pp. 1026-1033. https://doi.org/10.1016/j.bone.2009.03.671
Henriksen, Kim ; Neutzsky-Wulff, Anita V. ; Bonewald, Lynda ; Karsdal, Morten A. / Local communication on and within bone controls bone remodeling. In: Bone. 2009 ; Vol. 44, No. 6. pp. 1026-1033.
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