Local Regulation of Bone Cell Function

Lilian Plotkin, Nicoletta Bivi

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Citations (Scopus)

Abstract

Coordinated actions of osteoblasts and osteoclasts are required to maintain the integrity of the skeleton. This is achieved, in part, by a highly regulated array of molecules that are present in the bone microenvironment: cytokines and growth factors. Some of these molecules are produced locally by immature and mature bone cells and act in the cells that synthesize them (autocrine) or in the cells in their vicinity (paracrine). Locally produced factors may affect mainly osteoclasts [i.e. tumor necrosis factor ligand superfamily member 11/receptor activator of the NF-κB ligand (RANKL) and macrophage colony-stimulating factor 1 (M-CSF)], mainly osteoblasts [i.e. Wnts and insulin-like growth factor IGF)], or both cell types (i.e. interleukins and tumor necrosis factor). In addition, direct cell-cell interaction also contributes to the control of cell bone function. Cell-cell communication results from protein-protein interactions followed by activation of intracellular signaling pathways [such as Notch and ephrin-ephrin receptor (Eph)] or the formation of channels that allow the communication between the intracellular spaces of neighboring cells (such as connexin channels). Lastly, association of surface attachment molecules on the cell membrane with the extracellular matrix is essential for the regulation of osteoclast, osteoblast, and osteocyte survival and function.

Original languageEnglish
Title of host publicationBasic and Applied Bone Biology
PublisherElsevier Inc.
Pages47-73
Number of pages27
ISBN (Print)9780124160156
DOIs
StatePublished - Aug 12 2013

Fingerprint

Bone and Bones
Osteoclasts
Osteoblasts
Macrophage Colony-Stimulating Factor
Cell Communication
Eph Family Receptors
Ephrins
Intracellular Space
RANK Ligand
Osteocytes
Connexins
Interleukins
Somatomedins
Skeleton
Extracellular Matrix
Intercellular Signaling Peptides and Proteins
Proteins
Tumor Necrosis Factor-alpha
Cell Membrane
Cytokines

Keywords

  • Cell attachment
  • Cell-cell communication
  • Cytokine
  • Growth factor
  • Intracellular signaling

ASJC Scopus subject areas

  • Medicine(all)
  • Dentistry(all)

Cite this

Plotkin, L., & Bivi, N. (2013). Local Regulation of Bone Cell Function. In Basic and Applied Bone Biology (pp. 47-73). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-416015-6.00003-4

Local Regulation of Bone Cell Function. / Plotkin, Lilian; Bivi, Nicoletta.

Basic and Applied Bone Biology. Elsevier Inc., 2013. p. 47-73.

Research output: Chapter in Book/Report/Conference proceedingChapter

Plotkin, L & Bivi, N 2013, Local Regulation of Bone Cell Function. in Basic and Applied Bone Biology. Elsevier Inc., pp. 47-73. https://doi.org/10.1016/B978-0-12-416015-6.00003-4
Plotkin L, Bivi N. Local Regulation of Bone Cell Function. In Basic and Applied Bone Biology. Elsevier Inc. 2013. p. 47-73 https://doi.org/10.1016/B978-0-12-416015-6.00003-4
Plotkin, Lilian ; Bivi, Nicoletta. / Local Regulation of Bone Cell Function. Basic and Applied Bone Biology. Elsevier Inc., 2013. pp. 47-73
@inbook{5e246879fa3f4f599d4846b807fe392c,
title = "Local Regulation of Bone Cell Function",
abstract = "Coordinated actions of osteoblasts and osteoclasts are required to maintain the integrity of the skeleton. This is achieved, in part, by a highly regulated array of molecules that are present in the bone microenvironment: cytokines and growth factors. Some of these molecules are produced locally by immature and mature bone cells and act in the cells that synthesize them (autocrine) or in the cells in their vicinity (paracrine). Locally produced factors may affect mainly osteoclasts [i.e. tumor necrosis factor ligand superfamily member 11/receptor activator of the NF-κB ligand (RANKL) and macrophage colony-stimulating factor 1 (M-CSF)], mainly osteoblasts [i.e. Wnts and insulin-like growth factor IGF)], or both cell types (i.e. interleukins and tumor necrosis factor). In addition, direct cell-cell interaction also contributes to the control of cell bone function. Cell-cell communication results from protein-protein interactions followed by activation of intracellular signaling pathways [such as Notch and ephrin-ephrin receptor (Eph)] or the formation of channels that allow the communication between the intracellular spaces of neighboring cells (such as connexin channels). Lastly, association of surface attachment molecules on the cell membrane with the extracellular matrix is essential for the regulation of osteoclast, osteoblast, and osteocyte survival and function.",
keywords = "Cell attachment, Cell-cell communication, Cytokine, Growth factor, Intracellular signaling",
author = "Lilian Plotkin and Nicoletta Bivi",
year = "2013",
month = "8",
day = "12",
doi = "10.1016/B978-0-12-416015-6.00003-4",
language = "English",
isbn = "9780124160156",
pages = "47--73",
booktitle = "Basic and Applied Bone Biology",
publisher = "Elsevier Inc.",

}

TY - CHAP

T1 - Local Regulation of Bone Cell Function

AU - Plotkin, Lilian

AU - Bivi, Nicoletta

PY - 2013/8/12

Y1 - 2013/8/12

N2 - Coordinated actions of osteoblasts and osteoclasts are required to maintain the integrity of the skeleton. This is achieved, in part, by a highly regulated array of molecules that are present in the bone microenvironment: cytokines and growth factors. Some of these molecules are produced locally by immature and mature bone cells and act in the cells that synthesize them (autocrine) or in the cells in their vicinity (paracrine). Locally produced factors may affect mainly osteoclasts [i.e. tumor necrosis factor ligand superfamily member 11/receptor activator of the NF-κB ligand (RANKL) and macrophage colony-stimulating factor 1 (M-CSF)], mainly osteoblasts [i.e. Wnts and insulin-like growth factor IGF)], or both cell types (i.e. interleukins and tumor necrosis factor). In addition, direct cell-cell interaction also contributes to the control of cell bone function. Cell-cell communication results from protein-protein interactions followed by activation of intracellular signaling pathways [such as Notch and ephrin-ephrin receptor (Eph)] or the formation of channels that allow the communication between the intracellular spaces of neighboring cells (such as connexin channels). Lastly, association of surface attachment molecules on the cell membrane with the extracellular matrix is essential for the regulation of osteoclast, osteoblast, and osteocyte survival and function.

AB - Coordinated actions of osteoblasts and osteoclasts are required to maintain the integrity of the skeleton. This is achieved, in part, by a highly regulated array of molecules that are present in the bone microenvironment: cytokines and growth factors. Some of these molecules are produced locally by immature and mature bone cells and act in the cells that synthesize them (autocrine) or in the cells in their vicinity (paracrine). Locally produced factors may affect mainly osteoclasts [i.e. tumor necrosis factor ligand superfamily member 11/receptor activator of the NF-κB ligand (RANKL) and macrophage colony-stimulating factor 1 (M-CSF)], mainly osteoblasts [i.e. Wnts and insulin-like growth factor IGF)], or both cell types (i.e. interleukins and tumor necrosis factor). In addition, direct cell-cell interaction also contributes to the control of cell bone function. Cell-cell communication results from protein-protein interactions followed by activation of intracellular signaling pathways [such as Notch and ephrin-ephrin receptor (Eph)] or the formation of channels that allow the communication between the intracellular spaces of neighboring cells (such as connexin channels). Lastly, association of surface attachment molecules on the cell membrane with the extracellular matrix is essential for the regulation of osteoclast, osteoblast, and osteocyte survival and function.

KW - Cell attachment

KW - Cell-cell communication

KW - Cytokine

KW - Growth factor

KW - Intracellular signaling

UR - http://www.scopus.com/inward/record.url?scp=84902051831&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84902051831&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-416015-6.00003-4

DO - 10.1016/B978-0-12-416015-6.00003-4

M3 - Chapter

AN - SCOPUS:84902051831

SN - 9780124160156

SP - 47

EP - 73

BT - Basic and Applied Bone Biology

PB - Elsevier Inc.

ER -