Local Regulation of Bone Cell Function

Lilian I. Plotkin, Nicoletta Bivi

Research output: Chapter in Book/Report/Conference proceedingChapter

7 Scopus citations


Coordinated actions of osteoblasts and osteoclasts are required to maintain the integrity of the skeleton. This is achieved, in part, by a highly regulated array of molecules that are present in the bone microenvironment: cytokines and growth factors. Some of these molecules are produced locally by immature and mature bone cells and act in the cells that synthesize them (autocrine) or in the cells in their vicinity (paracrine). Locally produced factors may affect mainly osteoclasts [i.e. tumor necrosis factor ligand superfamily member 11/receptor activator of the NF-κB ligand (RANKL) and macrophage colony-stimulating factor 1 (M-CSF)], mainly osteoblasts [i.e. Wnts and insulin-like growth factor IGF)], or both cell types (i.e. interleukins and tumor necrosis factor). In addition, direct cell-cell interaction also contributes to the control of cell bone function. Cell-cell communication results from protein-protein interactions followed by activation of intracellular signaling pathways [such as Notch and ephrin-ephrin receptor (Eph)] or the formation of channels that allow the communication between the intracellular spaces of neighboring cells (such as connexin channels). Lastly, association of surface attachment molecules on the cell membrane with the extracellular matrix is essential for the regulation of osteoclast, osteoblast, and osteocyte survival and function.

Original languageEnglish (US)
Title of host publicationBasic and Applied Bone Biology
PublisherElsevier Inc.
Number of pages27
ISBN (Print)9780124160156
StatePublished - Aug 12 2013


  • Cell attachment
  • Cell-cell communication
  • Cytokine
  • Growth factor
  • Intracellular signaling

ASJC Scopus subject areas

  • Medicine(all)
  • Dentistry(all)

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  • Cite this

    Plotkin, L. I., & Bivi, N. (2013). Local Regulation of Bone Cell Function. In Basic and Applied Bone Biology (pp. 47-73). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-416015-6.00003-4