An amyloid tumor localized to the urethra was resected and shown by immunohistochemistry to contain fibril deposits that stained with antisera specific for λVI immunoglobulin light chain. The amino acid sequence of the fibril protein was homologous to λVI. Positive staining of subepithelial plasma cells with λVI specific monoclonal antibody was consistent with the hypothesis that the fibril precursor light chain protein is synthesized and processed locally to give this type of localized amyloidosis.
- Lambda VI (λ) light chain
- Localized amyloidosis
- Urinary tract
ASJC Scopus subject areas
- Pathology and Forensic Medicine