Local synthesis of amyloid fibril precursor in AL amyloidosis of the urinary tract

Kamran Hamidi Asl, Juris J. Liepnieks, Richard Bihrle, Merrill Benson

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

An amyloid tumor localized to the urethra was resected and shown by immunohistochemistry to contain fibril deposits that stained with antisera specific for λVI immunoglobulin light chain. The amino acid sequence of the fibril protein was homologous to λVI. Positive staining of subepithelial plasma cells with λVI specific monoclonal antibody was consistent with the hypothesis that the fibril precursor light chain protein is synthesized and processed locally to give this type of localized amyloidosis.

Original languageEnglish
Pages (from-to)49-54
Number of pages6
JournalAmyloid
Volume5
Issue number1
StatePublished - 1998

Fingerprint

Amyloidosis
Urinary Tract
Amyloid
Immunoglobulin Light Chains
Urethra
Plasma Cells
Immune Sera
Amino Acid Sequence
Proteins
Immunohistochemistry
Monoclonal Antibodies
Staining and Labeling
Light
Neoplasms

Keywords

  • Lambda VI (λ) light chain
  • Localized amyloidosis
  • Urethra
  • Urinary tract

ASJC Scopus subject areas

  • Medicine(all)
  • Pathology and Forensic Medicine

Cite this

Local synthesis of amyloid fibril precursor in AL amyloidosis of the urinary tract. / Asl, Kamran Hamidi; Liepnieks, Juris J.; Bihrle, Richard; Benson, Merrill.

In: Amyloid, Vol. 5, No. 1, 1998, p. 49-54.

Research output: Contribution to journalArticle

Asl, Kamran Hamidi ; Liepnieks, Juris J. ; Bihrle, Richard ; Benson, Merrill. / Local synthesis of amyloid fibril precursor in AL amyloidosis of the urinary tract. In: Amyloid. 1998 ; Vol. 5, No. 1. pp. 49-54.
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