Local synthesis of amyloid fibril precursor in AL amyloidosis of the urinary tract

Kamran Hamidi Asl, Juris J. Liepnieks, Richard Bihrle, Merrill D. Benson

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

An amyloid tumor localized to the urethra was resected and shown by immunohistochemistry to contain fibril deposits that stained with antisera specific for λVI immunoglobulin light chain. The amino acid sequence of the fibril protein was homologous to λVI. Positive staining of subepithelial plasma cells with λVI specific monoclonal antibody was consistent with the hypothesis that the fibril precursor light chain protein is synthesized and processed locally to give this type of localized amyloidosis.

Original languageEnglish (US)
Pages (from-to)49-54
Number of pages6
JournalAmyloid
Volume5
Issue number1
DOIs
StatePublished - Jan 1 1998

Keywords

  • Lambda VI (λ) light chain
  • Localized amyloidosis
  • Urethra
  • Urinary tract

ASJC Scopus subject areas

  • Medicine(all)
  • Pathology and Forensic Medicine

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