Localization of an ataxia-telangiectasia locus to a 3-cM interval on chromosome 11q23

Linkage analysis of 111 families by an international consortium

Tatiana Foroud, S. Wei, Y. Ziv, E. Sobel, E. Lange, A. Chao, T. Goradia, Y. Huo, A. Tolun, L. Chessa, P. Charmley, O. Sanal, N. Salman, C. Julier, P. Concannon, C. McConville, A. M R Taylor, Y. Shiloh, K. Lange, R. A. Gatti

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Linkage of at least two complementation groups of ataxia-telangiectasia (AT) to the chromosomal region 11q23 is now well established. We provide here an 18-point map of the surrounding genomic region, derived from linkage analysis of 40 CEPH families. On the basis of this map, 111 AT families from Turkey, Israel, England, Italy, and the United States were analyzed, localizing the AT gene(s) to an 8-cM sex-averaged interval between the markers STMY and D11S132/NCAM. A new Monte Carlo method for computing approximate location scores estimates this location as being at least 108 times more likely than the next most likely interval, with a support interval midway between STMY and D11S132 that is either 5.2 cM (sex-averaged and conservatively based on 3 lod scores from the maximum-location score) or 2.8 cM (male specific, based on a 2.72:1 interval-specific female-to-male distance ratio).

Original languageEnglish (US)
Pages (from-to)1263-1279
Number of pages17
JournalAmerican Journal of Human Genetics
Volume49
Issue number6
StatePublished - Dec 1991
Externally publishedYes

Fingerprint

Ataxia Telangiectasia
Chromosomes
Lod Score
Monte Carlo Method
Neural Cell Adhesion Molecules
Israel
Turkey
England
Italy
Genes

ASJC Scopus subject areas

  • Genetics

Cite this

Localization of an ataxia-telangiectasia locus to a 3-cM interval on chromosome 11q23 : Linkage analysis of 111 families by an international consortium. / Foroud, Tatiana; Wei, S.; Ziv, Y.; Sobel, E.; Lange, E.; Chao, A.; Goradia, T.; Huo, Y.; Tolun, A.; Chessa, L.; Charmley, P.; Sanal, O.; Salman, N.; Julier, C.; Concannon, P.; McConville, C.; Taylor, A. M R; Shiloh, Y.; Lange, K.; Gatti, R. A.

In: American Journal of Human Genetics, Vol. 49, No. 6, 12.1991, p. 1263-1279.

Research output: Contribution to journalArticle

Foroud, T, Wei, S, Ziv, Y, Sobel, E, Lange, E, Chao, A, Goradia, T, Huo, Y, Tolun, A, Chessa, L, Charmley, P, Sanal, O, Salman, N, Julier, C, Concannon, P, McConville, C, Taylor, AMR, Shiloh, Y, Lange, K & Gatti, RA 1991, 'Localization of an ataxia-telangiectasia locus to a 3-cM interval on chromosome 11q23: Linkage analysis of 111 families by an international consortium', American Journal of Human Genetics, vol. 49, no. 6, pp. 1263-1279.
Foroud, Tatiana ; Wei, S. ; Ziv, Y. ; Sobel, E. ; Lange, E. ; Chao, A. ; Goradia, T. ; Huo, Y. ; Tolun, A. ; Chessa, L. ; Charmley, P. ; Sanal, O. ; Salman, N. ; Julier, C. ; Concannon, P. ; McConville, C. ; Taylor, A. M R ; Shiloh, Y. ; Lange, K. ; Gatti, R. A. / Localization of an ataxia-telangiectasia locus to a 3-cM interval on chromosome 11q23 : Linkage analysis of 111 families by an international consortium. In: American Journal of Human Genetics. 1991 ; Vol. 49, No. 6. pp. 1263-1279.
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