Localization of insulin-like growth factor binding protein-2 messenger RNA during postnatal brain development: Correlation with insulin-like growth factors I and II

W. H. Lee, K. M. Michels, C. A. Bondy

Research output: Contribution to journalArticle

107 Citations (Scopus)

Abstract

Insulin-like growth factor binding protein-2 binds insulin-like growth factors I and II with high affinity and modulates the interaction of these ligands with the type I insulin-like growth factor receptor. Previously we have shown that insulin-like growth factor binding protein-2 and insulin-like growth factor-I gene expression are spatiotemporally co-ordinated in the developing retina and cerebellum. The present study examined other brain regions and found a similar correlation in insulin-like growth factor binding protein-2 and insulin-like growth factor-I gene expression in relay stations of developing sensory and cerebellar networks of the rat. In these sites, as in the cerebellum and retina, insulin-like growth factor-I messenger RNA is localized in the principal or projection neurons and insulin-like growth factor binding protein-2 messenger RNA is localized in surrounding astroglia. Outside these sensory relay centers, the relationship of insulin-like growth factor binding protein-2 to insulin-like growth factor-I gene expression is not so well defined. In the hippocampal formation, insulin-like growth factor-I messenger RNA is present in large interneurons and insulin-like growth factor binding protein-2 messenger RNA in regional astrocytes; their timing is co-ordinated, with peak levels seen about postnatal day 12, but their anatomical association is not apparent. The least degree of correlation between local insulin-like growth factor-I and insulin-like growth factor binding protein-2 gene expression is found in the neocortex, where insulin-like growth factor-I is abundant in scattered large neurons from postnatal days 3 to 20. In contrast, insulin-like growth factor binding protein-2 messenger RNA is widely expressed throughout the neocortex from before birth to about postnatal day 12, in a pattern consistent with expression by nascent astroglia. Insulin-like growth factor binding protein-2 gene expression is greatly reduced throughout the brain by the third week after birth; in response to optic nerve transection, however, there is a resurgence of gene expression for this factor by activated astrocytes in affected retinal target regions. Insulin-like growth factor binding protein-2 and insulin-like growth factor-II messenger RNAs are co-localized in the choroid plexus and leptomeninges from the time of birth onward without diminution. In summary, insulin-like growth factor binding protein-2 demonstrates complex patterns of gene expression during postnatal brain development-some of which appear to be closely related to local insulin-like growth factor synthesis and some of which appear independent of it. The spatiotemporal correlation between astroglial insulin-like growth factor binding protein-2 and neuronal insulin-like growth factor-I expression is restricted to maturing sensory and cerebellar projection systems, suggesting a system-specific function for insulin-like growth factor-I and insulin-like growth factor binding protein-2 interaction in the differentiation of these centers.

Original languageEnglish (US)
Pages (from-to)251-265
Number of pages15
JournalNeuroscience
Volume53
Issue number1
DOIs
StatePublished - 1993
Externally publishedYes

Fingerprint

Insulin-Like Growth Factor Binding Protein 2
Insulin-Like Growth Factor II
Insulin-Like Growth Factor I
Messenger RNA
Brain
Gene Expression
Astrocytes
Neocortex
Parturition
Cerebellum
Retina
Optic Nerve Injuries
Neurons
IGF Type 1 Receptor
Choroid Plexus
Interneurons
Somatomedins

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Localization of insulin-like growth factor binding protein-2 messenger RNA during postnatal brain development : Correlation with insulin-like growth factors I and II. / Lee, W. H.; Michels, K. M.; Bondy, C. A.

In: Neuroscience, Vol. 53, No. 1, 1993, p. 251-265.

Research output: Contribution to journalArticle

@article{25703d3b19de4b0199848f3eb90be8f6,
title = "Localization of insulin-like growth factor binding protein-2 messenger RNA during postnatal brain development: Correlation with insulin-like growth factors I and II",
abstract = "Insulin-like growth factor binding protein-2 binds insulin-like growth factors I and II with high affinity and modulates the interaction of these ligands with the type I insulin-like growth factor receptor. Previously we have shown that insulin-like growth factor binding protein-2 and insulin-like growth factor-I gene expression are spatiotemporally co-ordinated in the developing retina and cerebellum. The present study examined other brain regions and found a similar correlation in insulin-like growth factor binding protein-2 and insulin-like growth factor-I gene expression in relay stations of developing sensory and cerebellar networks of the rat. In these sites, as in the cerebellum and retina, insulin-like growth factor-I messenger RNA is localized in the principal or projection neurons and insulin-like growth factor binding protein-2 messenger RNA is localized in surrounding astroglia. Outside these sensory relay centers, the relationship of insulin-like growth factor binding protein-2 to insulin-like growth factor-I gene expression is not so well defined. In the hippocampal formation, insulin-like growth factor-I messenger RNA is present in large interneurons and insulin-like growth factor binding protein-2 messenger RNA in regional astrocytes; their timing is co-ordinated, with peak levels seen about postnatal day 12, but their anatomical association is not apparent. The least degree of correlation between local insulin-like growth factor-I and insulin-like growth factor binding protein-2 gene expression is found in the neocortex, where insulin-like growth factor-I is abundant in scattered large neurons from postnatal days 3 to 20. In contrast, insulin-like growth factor binding protein-2 messenger RNA is widely expressed throughout the neocortex from before birth to about postnatal day 12, in a pattern consistent with expression by nascent astroglia. Insulin-like growth factor binding protein-2 gene expression is greatly reduced throughout the brain by the third week after birth; in response to optic nerve transection, however, there is a resurgence of gene expression for this factor by activated astrocytes in affected retinal target regions. Insulin-like growth factor binding protein-2 and insulin-like growth factor-II messenger RNAs are co-localized in the choroid plexus and leptomeninges from the time of birth onward without diminution. In summary, insulin-like growth factor binding protein-2 demonstrates complex patterns of gene expression during postnatal brain development-some of which appear to be closely related to local insulin-like growth factor synthesis and some of which appear independent of it. The spatiotemporal correlation between astroglial insulin-like growth factor binding protein-2 and neuronal insulin-like growth factor-I expression is restricted to maturing sensory and cerebellar projection systems, suggesting a system-specific function for insulin-like growth factor-I and insulin-like growth factor binding protein-2 interaction in the differentiation of these centers.",
author = "Lee, {W. H.} and Michels, {K. M.} and Bondy, {C. A.}",
year = "1993",
doi = "10.1016/0306-4522(93)90303-W",
language = "English (US)",
volume = "53",
pages = "251--265",
journal = "Neuroscience",
issn = "0306-4522",
publisher = "Elsevier Limited",
number = "1",

}

TY - JOUR

T1 - Localization of insulin-like growth factor binding protein-2 messenger RNA during postnatal brain development

T2 - Correlation with insulin-like growth factors I and II

AU - Lee, W. H.

AU - Michels, K. M.

AU - Bondy, C. A.

PY - 1993

Y1 - 1993

N2 - Insulin-like growth factor binding protein-2 binds insulin-like growth factors I and II with high affinity and modulates the interaction of these ligands with the type I insulin-like growth factor receptor. Previously we have shown that insulin-like growth factor binding protein-2 and insulin-like growth factor-I gene expression are spatiotemporally co-ordinated in the developing retina and cerebellum. The present study examined other brain regions and found a similar correlation in insulin-like growth factor binding protein-2 and insulin-like growth factor-I gene expression in relay stations of developing sensory and cerebellar networks of the rat. In these sites, as in the cerebellum and retina, insulin-like growth factor-I messenger RNA is localized in the principal or projection neurons and insulin-like growth factor binding protein-2 messenger RNA is localized in surrounding astroglia. Outside these sensory relay centers, the relationship of insulin-like growth factor binding protein-2 to insulin-like growth factor-I gene expression is not so well defined. In the hippocampal formation, insulin-like growth factor-I messenger RNA is present in large interneurons and insulin-like growth factor binding protein-2 messenger RNA in regional astrocytes; their timing is co-ordinated, with peak levels seen about postnatal day 12, but their anatomical association is not apparent. The least degree of correlation between local insulin-like growth factor-I and insulin-like growth factor binding protein-2 gene expression is found in the neocortex, where insulin-like growth factor-I is abundant in scattered large neurons from postnatal days 3 to 20. In contrast, insulin-like growth factor binding protein-2 messenger RNA is widely expressed throughout the neocortex from before birth to about postnatal day 12, in a pattern consistent with expression by nascent astroglia. Insulin-like growth factor binding protein-2 gene expression is greatly reduced throughout the brain by the third week after birth; in response to optic nerve transection, however, there is a resurgence of gene expression for this factor by activated astrocytes in affected retinal target regions. Insulin-like growth factor binding protein-2 and insulin-like growth factor-II messenger RNAs are co-localized in the choroid plexus and leptomeninges from the time of birth onward without diminution. In summary, insulin-like growth factor binding protein-2 demonstrates complex patterns of gene expression during postnatal brain development-some of which appear to be closely related to local insulin-like growth factor synthesis and some of which appear independent of it. The spatiotemporal correlation between astroglial insulin-like growth factor binding protein-2 and neuronal insulin-like growth factor-I expression is restricted to maturing sensory and cerebellar projection systems, suggesting a system-specific function for insulin-like growth factor-I and insulin-like growth factor binding protein-2 interaction in the differentiation of these centers.

AB - Insulin-like growth factor binding protein-2 binds insulin-like growth factors I and II with high affinity and modulates the interaction of these ligands with the type I insulin-like growth factor receptor. Previously we have shown that insulin-like growth factor binding protein-2 and insulin-like growth factor-I gene expression are spatiotemporally co-ordinated in the developing retina and cerebellum. The present study examined other brain regions and found a similar correlation in insulin-like growth factor binding protein-2 and insulin-like growth factor-I gene expression in relay stations of developing sensory and cerebellar networks of the rat. In these sites, as in the cerebellum and retina, insulin-like growth factor-I messenger RNA is localized in the principal or projection neurons and insulin-like growth factor binding protein-2 messenger RNA is localized in surrounding astroglia. Outside these sensory relay centers, the relationship of insulin-like growth factor binding protein-2 to insulin-like growth factor-I gene expression is not so well defined. In the hippocampal formation, insulin-like growth factor-I messenger RNA is present in large interneurons and insulin-like growth factor binding protein-2 messenger RNA in regional astrocytes; their timing is co-ordinated, with peak levels seen about postnatal day 12, but their anatomical association is not apparent. The least degree of correlation between local insulin-like growth factor-I and insulin-like growth factor binding protein-2 gene expression is found in the neocortex, where insulin-like growth factor-I is abundant in scattered large neurons from postnatal days 3 to 20. In contrast, insulin-like growth factor binding protein-2 messenger RNA is widely expressed throughout the neocortex from before birth to about postnatal day 12, in a pattern consistent with expression by nascent astroglia. Insulin-like growth factor binding protein-2 gene expression is greatly reduced throughout the brain by the third week after birth; in response to optic nerve transection, however, there is a resurgence of gene expression for this factor by activated astrocytes in affected retinal target regions. Insulin-like growth factor binding protein-2 and insulin-like growth factor-II messenger RNAs are co-localized in the choroid plexus and leptomeninges from the time of birth onward without diminution. In summary, insulin-like growth factor binding protein-2 demonstrates complex patterns of gene expression during postnatal brain development-some of which appear to be closely related to local insulin-like growth factor synthesis and some of which appear independent of it. The spatiotemporal correlation between astroglial insulin-like growth factor binding protein-2 and neuronal insulin-like growth factor-I expression is restricted to maturing sensory and cerebellar projection systems, suggesting a system-specific function for insulin-like growth factor-I and insulin-like growth factor binding protein-2 interaction in the differentiation of these centers.

UR - http://www.scopus.com/inward/record.url?scp=0027400362&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027400362&partnerID=8YFLogxK

U2 - 10.1016/0306-4522(93)90303-W

DO - 10.1016/0306-4522(93)90303-W

M3 - Article

C2 - 7682300

AN - SCOPUS:0027400362

VL - 53

SP - 251

EP - 265

JO - Neuroscience

JF - Neuroscience

SN - 0306-4522

IS - 1

ER -