Localization of PiUS, a stimulator of cellular phosphate uptake to human chromosome 3p21.3

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Abstract

A novel gene, PiUS, was recently cloned and shown to increase phosphates uptake when expressed in oocytes, indicating that it may be an important regulator of cellular phosphate homeostasis. The phosphate wasting disease autosomal dominant hypophosphatemic rickets (ADHR) was previously mapped to chromosome 12p13 by linkage analysis. PiUS' role as a modulator of phosphate transport, as well as its intestinal and renal expression made the gene an appropriate candidate for ADHR. The purpose of our study was to determine the chromosomal localization of the human PiUS gene through the use of somatic cell hybrids and radiation hybrid mapping. In the present work, PiUS was localized to human chromosome 3p21.3 and is therefore not the ADHR gene.

Original languageEnglish
Pages (from-to)71-74
Number of pages4
JournalSomatic Cell and Molecular Genetics
Volume24
Issue number1
StatePublished - Jan 1998

Fingerprint

Human Chromosomes
Phosphates
Radiation Hybrid Mapping
Genes
Wasting Syndrome
Hybrid Cells
Oocytes
Homeostasis
Chromosomes
Kidney
Gene Expression
Autosomal Dominant Hypophosphatemic Rickets

ASJC Scopus subject areas

  • Genetics
  • Cell Biology

Cite this

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title = "Localization of PiUS, a stimulator of cellular phosphate uptake to human chromosome 3p21.3",
abstract = "A novel gene, PiUS, was recently cloned and shown to increase phosphates uptake when expressed in oocytes, indicating that it may be an important regulator of cellular phosphate homeostasis. The phosphate wasting disease autosomal dominant hypophosphatemic rickets (ADHR) was previously mapped to chromosome 12p13 by linkage analysis. PiUS' role as a modulator of phosphate transport, as well as its intestinal and renal expression made the gene an appropriate candidate for ADHR. The purpose of our study was to determine the chromosomal localization of the human PiUS gene through the use of somatic cell hybrids and radiation hybrid mapping. In the present work, PiUS was localized to human chromosome 3p21.3 and is therefore not the ADHR gene.",
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AB - A novel gene, PiUS, was recently cloned and shown to increase phosphates uptake when expressed in oocytes, indicating that it may be an important regulator of cellular phosphate homeostasis. The phosphate wasting disease autosomal dominant hypophosphatemic rickets (ADHR) was previously mapped to chromosome 12p13 by linkage analysis. PiUS' role as a modulator of phosphate transport, as well as its intestinal and renal expression made the gene an appropriate candidate for ADHR. The purpose of our study was to determine the chromosomal localization of the human PiUS gene through the use of somatic cell hybrids and radiation hybrid mapping. In the present work, PiUS was localized to human chromosome 3p21.3 and is therefore not the ADHR gene.

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