Localization of the human cd59 gene by fluorescence in situ hybridization and pulsed-field gel electrophoresis

B. Heckl-Östreicher, Susanne Ragg, M. Drechsler, H. Scherthan, B. Royer-Pokora

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

We have localized the human CD59 gene encoding a membrane protein that inhibits cell lysis by the membrane-attack complex of the homologous complement system. Using chromosomal in situ suppression hybridization and pulsed-field gel electrophoresis, we mapped this gene to chromosome 11pl3, distal to the breakpoint of acute T-cell leukemia and proximal to the locus of the Wilms tumor gene on a 30-kb Sac II fragment.

Original languageEnglish (US)
Pages (from-to)144-146
Number of pages3
JournalCytogenetic and Genome Research
Volume63
Issue number3
DOIs
StatePublished - 1993
Externally publishedYes

Fingerprint

Pulsed Field Gel Electrophoresis
Fluorescence In Situ Hybridization
Wilms' Tumor Genes
Complement Membrane Attack Complex
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Genes
In Situ Hybridization
Membrane Proteins
Chromosomes
Cell Membrane

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Genetics(clinical)
  • Cell Biology

Cite this

Localization of the human cd59 gene by fluorescence in situ hybridization and pulsed-field gel electrophoresis. / Heckl-Östreicher, B.; Ragg, Susanne; Drechsler, M.; Scherthan, H.; Royer-Pokora, B.

In: Cytogenetic and Genome Research, Vol. 63, No. 3, 1993, p. 144-146.

Research output: Contribution to journalArticle

Heckl-Östreicher, B. ; Ragg, Susanne ; Drechsler, M. ; Scherthan, H. ; Royer-Pokora, B. / Localization of the human cd59 gene by fluorescence in situ hybridization and pulsed-field gel electrophoresis. In: Cytogenetic and Genome Research. 1993 ; Vol. 63, No. 3. pp. 144-146.
@article{edcb327f2dd742798f81ebd55aed8917,
title = "Localization of the human cd59 gene by fluorescence in situ hybridization and pulsed-field gel electrophoresis",
abstract = "We have localized the human CD59 gene encoding a membrane protein that inhibits cell lysis by the membrane-attack complex of the homologous complement system. Using chromosomal in situ suppression hybridization and pulsed-field gel electrophoresis, we mapped this gene to chromosome 11pl3, distal to the breakpoint of acute T-cell leukemia and proximal to the locus of the Wilms tumor gene on a 30-kb Sac II fragment.",
author = "B. Heckl-{\"O}streicher and Susanne Ragg and M. Drechsler and H. Scherthan and B. Royer-Pokora",
year = "1993",
doi = "10.1159/000133522",
language = "English (US)",
volume = "63",
pages = "144--146",
journal = "Cytogenetic and Genome Research",
issn = "1424-8581",
publisher = "S. Karger AG",
number = "3",

}

TY - JOUR

T1 - Localization of the human cd59 gene by fluorescence in situ hybridization and pulsed-field gel electrophoresis

AU - Heckl-Östreicher, B.

AU - Ragg, Susanne

AU - Drechsler, M.

AU - Scherthan, H.

AU - Royer-Pokora, B.

PY - 1993

Y1 - 1993

N2 - We have localized the human CD59 gene encoding a membrane protein that inhibits cell lysis by the membrane-attack complex of the homologous complement system. Using chromosomal in situ suppression hybridization and pulsed-field gel electrophoresis, we mapped this gene to chromosome 11pl3, distal to the breakpoint of acute T-cell leukemia and proximal to the locus of the Wilms tumor gene on a 30-kb Sac II fragment.

AB - We have localized the human CD59 gene encoding a membrane protein that inhibits cell lysis by the membrane-attack complex of the homologous complement system. Using chromosomal in situ suppression hybridization and pulsed-field gel electrophoresis, we mapped this gene to chromosome 11pl3, distal to the breakpoint of acute T-cell leukemia and proximal to the locus of the Wilms tumor gene on a 30-kb Sac II fragment.

UR - http://www.scopus.com/inward/record.url?scp=0027245769&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027245769&partnerID=8YFLogxK

U2 - 10.1159/000133522

DO - 10.1159/000133522

M3 - Article

VL - 63

SP - 144

EP - 146

JO - Cytogenetic and Genome Research

JF - Cytogenetic and Genome Research

SN - 1424-8581

IS - 3

ER -